化合物简介
Alvimopan (trade name Entereg) is a drug which behaves as a peripherally acting μ-opioid antagonist. With limited ability to cross the blood–brain barrier, many of the undesirable side-effects of the opioid agonists such as constipation are minimized without affecting analgesia or precipitating withdrawal. It is currently only Food and Drug Administration approved for the treatment of postoperative ileus which it received in May 2008.
基本信息
中文名称
爱维莫潘
英文名称
Alvimopan
中文别名
2-([(2S)-2-([(3R,4R)-4-(3-羟基苯基)-3,4-二甲基哌啶-1-基]甲基)-3-苯基丙酰]氨基)乙酸
英文别名
Unii-Q153V49p3z
CAS号
156053-89-3
分子式
C25H32N2O4
分子量
424.533
精确质量
424.236
PSA
89.87
LOGP
3.3802
编号系统
MDL号
MFCD25970564
物化性质
密度
1.166g/cm3
沸点
684.1ºC at 760mmHg
熔点
210-213ºC
闪点
367.5ºC
安全信息
海关编码
2933399090
危险性防范说明
P273; P280; P305 + P351 + P338; P337 + P313; P391
危险标志
GHS07, GHS09
信号词
Warning
危险性描述
H315; H319; H400
合成路线
145603-86-7
