化合物简介
3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis).
基本信息
中文名称
3-溴-2-氟苯甲酸
英文名称
3-Bromo-2-fluorobenzoic acid
中文别名
2-氟-3-溴苯甲酸
英文别名
2-fluoro-3-bromobenzoic acid、3-Bromo-2-Fluorobenzoic acid、3-Bromo-2-fluoro-benzoic acid
CAS号
161957-56-8
分子式
C7H4BrFO2
分子量
219.008
精确质量
217.938
PSA
37.3
LOGP
2.2864
编号系统
MDL号
MFCD00665763
物化性质
熔点
168 °C
安全信息
海关编码
2916399090
危险品标志
Xi
海关数据
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