化合物简介
Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension. In October 2011 the U.S. Food and Drug Administration (FDA) approved Cialis for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction (ED) when the conditions coincide. It initially was developed by the biotechnology company ICOS, and then again developed and marketed world-wide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialis tablets, in 2.5mg, 5mg, 10mg, and 20mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40mg (two 20-mg tablets) once daily.
基本信息
中文名称
他达那非
英文名称
Tildenafil
中文别名
西力士、他地那非
英文别名
Cialis、(6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a tetrahydropyrazino [1\',2\':1,6] pyrido[3,4b] indole1,4(6H,7H)-dione、(6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1\',2\':1,6]\r\npyrido[3,4-b]indole-1,4-dione
CAS号
171596-29-5
分子式
C22H19N3O4
分子量
389.404
精确质量
389.138
PSA
74.87
LOGP
2.0871
编号系统
MDL号
MFCD07771966
物化性质
外观与性状
灰白色水晶般的固体
密度
1.51 g/cm3
沸点
679.1ºC at 760 mmHg
熔点
298-300ºC
闪点
364.5ºC
折射率
1.705
蒸汽压
5.29E-13mmHg at 25°C
生产方法及用途
用途
磷酸二酯酶5抑制剂,用于治疗男性勃起功能障碍。
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