化合物简介
Varespladib is an inhibitor of the IIa, V, and X isoforms of secretory phospholipase A2 (sPLA2). The molecule acts as an anti-inflammatory agent by disrupting the first step of the arachidonic acid pathway of inflammation. From 2006 to 2012, varespladib was under active investigation by Anthera Pharmaceuticals as a potential therapy for several inflammatory diseases, including acute coronary syndrome and acute chest syndrome. The trial was halted in March 2012 due to inadequate efficacy.
基本信息
中文名称
伐瑞拉迪钠
英文名称
sodium,2-(1-benzyl-2-ethyl-3-oxamoylindol-4-yl)oxyacetate
中文别名
英文别名
UNII-F6M52CDT0W、Varespladib sodium
CAS号
172733-42-5
分子式
C21H19N2NaO5
分子量
402.376
精确质量
402.119
PSA
114.45
LOGP
1.749
编号系统
UNII
F6M52CDT0W
合成路线