化合物简介
NO-Aspirin 1 is a hybrid molecule of aspirin and a nitric oxide (NO) donor. It contains an ester linkage, that when cleaved by esterases in the gut, liver, and plasma releases salicylate and an NO-releasing moiety. It also prevents restinosiis, inhibits proliferation of vascular smooth muscle cells, reduces infarct ssize following cardiac ischemia, and exhibits strong chemopreventative effects against colon cancer development.
基本信息
中文名称
2-(乙酰氧基)-苯甲酸 3-[(硝基氧基)甲基]苯基酯
英文名称
[3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate
中文别名
英文别名
nitroaspirin、3-nitrooxyphenyl acetylsalicylate、NO-ASA、Ncx 4016、m-NO-ASA、m-NO-aspirin
CAS号
175033-36-0
分子式
C16H13NO7
分子量
331.277
精确质量
331.069
PSA
107.65
LOGP
3.0626
编号系统
UNII
EH04H13L6B
物化性质
密度
1.347g/cm3
沸点
499.3ºC at 760mmHg
熔点
61-62ºC
闪点
214.3ºC
折射率
1.58
蒸汽压
4.21E-10mmHg at 25°C
