化合物简介
Lasofoxifene (INN) (brand name Fablyn) is a non-steroidal selective estrogen receptor modulator (SERM) which is marketed by Pfizer for the prevention and treatment of osteoporosis and for the treatment of vaginal atrophy, and the result of an exclusive research collaboration with Ligand Pharmaceuticals (LGND). It also appears to have had a statistically significant effect of reducing breast cancer in women according to a study published in The Journal of the National Cancer Institute.
基本信息
中文名称
拉索昔芬
英文名称
Lasofoxifene
中文别名
(5R,6S)-5,6,7,8-四氢-6-苯基-5-(4-(2-(1-吡咯烷基)乙氧基)苯基)-2-萘酚
英文别名
lasofoxifen、CP-336,156
CAS号
180916-16-9
分子式
C28H31NO2
分子量
413.551
精确质量
413.235
PSA
32.7
LOGP
5.6666
编号系统
UNII
337G83N988
物化性质
密度
1.15g/cm3
沸点
572.4ºC at 760mmHg
闪点
300ºC
折射率
1.613
蒸汽压
1.05E-13mmHg at 25°C
合成路线
