化合物简介
Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, being developed by Bristol-Myers Squibb, that is currently in phase I/II clinical trials. The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life. However, ravuconazole has limited activity against species of Fusarium, Scedosporium, and Zygomycetes.
基本信息
中文名称
雷夫康唑
英文名称
Ravuconazole
中文别名
里氟康唑、4-[2-[(2R,3r)-3-(2,4-二氟苯基)-3-羟基-4-(1,2,4-噻唑)丁基]-1,3-噻唑]苯甲腈
英文别名
RCZ、4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile
CAS号
182760-06-1
分子式
C22H17F2N5OS
分子量
437.465
精确质量
437.112
PSA
115.86
LOGP
4.24298
编号系统
UNII
95YH599JWV
物化性质
密度
1.38g/cm3
沸点
674.9ºC at 760 mmHg
闪点
362ºC
折射率
1.665
蒸汽压
3.89E-19mmHg at 25°C
安全信息
危险性防范说明
P280; P305 + P351 + P338; P337 + P313
信号词
Warning
危险标志
GHS07
危险性描述
H315; H319; H335
合成路线
上游原料
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