百科

卡巴他赛

卡巴他赛

CAS号：183133-96-2

英文名：Cabazitaxel

分子式

C45H57NO14

熔点

密度

分子量

835.932

沸点

溶解度

信号词

危险品标志

若想填写更详细的询价信息，请点击进入询价页面

点我

化合物简介

A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.

基本信息

中文名称

卡巴他赛

英文名称

Cabazitaxel

中文别名

10Beta-二甲氧基多西紫杉醇、卡巴他塞、达拉菲尼

英文别名

Cabazitaxelum、Jevtana、TXD258、XRP-6258、CABAZITAXEL、Taxoid XRP6258、(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04\'7]heptadec-13-en-2-ylbenzoate、Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1Hcyclodeca[3,4]benz[1,2-b]oxet-9-ylester, (αR,βS)-、Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-

CAS号

183133-96-2

分子式

C45H57NO14

分子量

835.932

精确质量

835.378

PSA

202.45

LOGP

4.9587

编号系统

UNII

51F690397J

安全信息

海关编码

2942000000

合成路线

2'-TES-cabazitaxel

2'-TES-cabazitaxel

卡巴他赛

上游原料

共找到40个上游原料 >

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-4,6-bis((1,3-dithian-2-yl)oxy)-12b-acetoxy-9,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-4,6-bis((1,3-dithian-2-yl)oxy)-12b-acetoxy-9,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

卡巴他赛N-1

卡巴他赛N-1

2'-THP-7,10-TROC-docetaxel

2'-THP-7,10-TROC-docetaxel

13-acetyl-7,10-dimethoxy-10-DAB

13-acetyl-7,10-dimethoxy-10-DAB

2'-THP-docetaxel

2'-THP-docetaxel

(4S,5R)-3-叔丁氧基-2-(4-甲氧基苯基)-4-苯基-5-恶唑烷羧酸

(4S,5R)-3-叔丁氧基-2-(4-甲氧基苯基)-4-苯基-5-恶唑烷羧酸

上游原料

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-4,6-bis((1,3-dithian-2-yl)oxy)-12b-acetoxy-9,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate 卡巴他赛N-1 2'-THP-7,10-TROC-docetaxel 13-acetyl-7,10-dimethoxy-10-DAB 2'-THP-docetaxel (4S,5R)-3-叔丁氧基-2-(4-甲氧基苯基)-4-苯基-5-恶唑烷羧酸 10-O-methyl-7-O-triethylsilyl-10-DAB 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-13-(triethylsilyloxy)-11-taxene 2'-TBS-docetaxel 2’-THP-cabazitaxel 2’-(1-ethoxyethyl)cabazitaxel (2R,3S)-N-Boc-3-phenylisoserine benzyl ester 7,10-methylthiomethyl-10-DAB (3R,4S)-3-(三乙基硅氧基)-4-苯基-2-氧-氮杂环丁-1-甲酸叔丁酯 7,13-diacetyl baccatin III 2'-TES-cabazitaxel Benzenepropanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]oxy]-β-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]-, phenylmethyl ester, (αR,βS)- 2'-三乙基硅烷基多西他赛 10-O-methyl-7-O-1,3-benzodithiolan-2-yl-10-DAB 10-O-methyl-10-DAB (R)-N-benzylidene-2-methylpropane-2-sulfinamide 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-11-taxene-13α-yl (2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate (4S,5R)-5-benzyl 3-tert-butyl 2-(4-methoxyphenyl)-4-phenyloxazolidine-3,5-dicarboxylate 7β,10β-二甲氧基多西紫杉醇 10-脱乙酰基巴卡丁 III 2'-TBS-7,10-TROC-docetaxel 2'-TES-7,10-TROC-docetaxel 7,10-di-O-1,3-dithian-2-yl-10-DAB 13-acetyl-10-deacetyl baccatin III 7-O-(三乙基硅烷基)-10-去乙酰基浆果赤霉素III 7,10-di-O-1,3-benzodithiolan-2-yl-10-DAB 2’-TBS-cabazitaxel 7,13-二-O-(三乙基硅烷基)-10-去乙酰基浆果赤霉素III (2α,5β,7β,10β,13α)-4-acetoxy-13-{(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxy}-1-hydroxy-7,10-di-O-1,3-benzodithiolan-2-yl-9-oxo-5,20-epoxy-tax-11-en-2-yl benzoate