百科

他莫瑞林

CAS号：193079-69-5

英文名：Tabimorelin

分子式

C68H84N8O10

熔点

密度

1.146g/cm3

分子量

1173.44

沸点

794.4ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.

基本信息

中文名称

他莫瑞林

英文名称

Tabimorelin

中文别名

英文别名

(E)-5-amino-N,5-dimethyl-N-[(2R)-1-[methyl-[(2R)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide

CAS号

193079-69-5

分子式

C68H84N8O10

分子量

1173.44

精确质量

1172.63

PSA

266.08

LOGP

9.3114

物化性质

密度

1.146g/cm3

沸点

794.4ºC at 760mmHg

闪点

434.2ºC

折射率

1.6

蒸汽压

0mmHg at 25°C

合成路线

193085-20-0

((3E)-1,1-Dimethyl-4-(N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)but-3-enyl)carbamic acid tert-butyl ester

上游原料

3-羟基-1,1-二甲基丙基-氨基甲酸叔丁酯

193085-18-6

N-Methyl-N-((R)-1-(methylcarbamoyl)-2-phenylethyl)carbamic acid tert-butyl ester

181646-38-8

(1,1-dimethyl-3-oxo-propyl)-carbamic acid tert-butyl ester

193085-20-0

((3E)-1,1-Dimethyl-4-(N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)but-3-enyl)carbamic acid tert-butyl ester

193150-11-7

(R)-N-Methyl-2-methylamino-3-phenylpropionamide

上游原料

N-Boc-3-氨基-3-甲基丁酸 3-羟基-1,1-二甲基丙基-氨基甲酸叔丁酯 N-Methyl-N-((R)-1-(methylcarbamoyl)-2-phenylethyl)carbamic acid tert-butyl ester (1,1-dimethyl-3-oxo-propyl)-carbamic acid tert-butyl ester ((3E)-1,1-Dimethyl-4-(N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)but-3-enyl)carbamic acid tert-butyl ester (R)-N-Methyl-2-methylamino-3-phenylpropionamide (alphaR)-alpha-[[(1,1-二甲基乙氧基)羰基]甲基氨基]-2-萘丙酸 N-Methyl-N-{(1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl}carbamic acid tert-butyl ester (2R)-N-Methyl-2-methylamino-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)-3-(2-naphthyl)propionamide ethyl (2E)-5-(tert-butoxycarbonylamino)-5-methylhex-2-enoate Boc-N-甲基-L-苯丙氨酸 (2E)-5-(tert-butyloxycarbonylamino)-5-methylhex-2-enoic acid