合成路线
(2S,6Z,9S,10E)-9-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-11-(2-methyl-1,3-thiazol-4-yl)undeca-6,10-dienal
CAS号：193146-27-9
英文名：(2S,6Z,9S,10E)-9-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-11-(2-methyl-1,3-thiazol-4-yl)undeca-6,10-dienal
分子式：C24H41NO2SSi
分子量：435.738
上游原料
(S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-pentyl-borane
(3S,5Z)-6,10-dimethyl-2-[(2-methylthiazol-4-yl)methyl]undeca-1,5,10-trien-3-yl pivaloate
(3S,1E,5Z)-2,6,10-trimethyl-1-(2-methylthiazol-4-yl)undeca-1,5,10-trien-3-ol
(6Z,10E)-(2S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dienenitrile
(2S,3S)-{1-[1-(4-methoxybenzyloxy)ethyl]but-3-enyloxy}dimethyl(3-methylbut-3-enyloxy)silane
(2E,6E)-(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-4-methyl-pentyl]-6-methyl-7-(2-methyl-thiazol-4-yl)-hepta-2,6-dien-1-ol
6-tert-butyldimethylsilyloxy-5-methylhexan-1-ol
下游产品
(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)-5-氧代-十七-12,16-二烯酸
(3S,6R,7S,8S,12Z,15S,16E)-1,3,7,15-四-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮
(8Z,12E)-(2S,3R,4S,11S)-1-{1-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-cyclopropyl}-11-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4,8,12-tetramethyl-13-(2-methyl-thiazol-4-yl)-trideca-8,12-dien-1-one
(12Z,16E)-(3S,6R,7S,8S,15S)-3,7,15-tris-(tert-butyl-dimethyl-silanyloxy)-1-((S)-10,10-dimethyl-3,3-dioxo-3-thia-4-aza-tricyclo[5.2.1.0]dec-4-yl)-4,4,6,8,12,16-hexamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-diene-1,5-dione
埃博霉素B
(3S,6R,7S,8S,12Z,15S,16E)-1,3,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-7-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七烷基-12,16-二烯-5-酮
Epothilone D
(8Z,12E)-(2R,3S,4S,11S)-1-{1-[(S)-1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-cyclopropyl}-11-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4,8,12-tetramethyl-13-(2-methyl-thiazol-4-yl)-trideca-8,12-dien-1-one
[4S-[4R*,7S*,8R*,9R*,15R*(E)]]-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-1-aza-13(Z)-cyclohexadecene-2,6-dione
(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-1-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮
