(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-1-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮

(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-1-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮

CAS号：193146-53-1

英文名：(3S,7S,8S,12Z,15S,16E)-3,7,15-tris[[tert-butyl(dimethyl)silyl]oxy]-1-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadeca-12,16-dien-5-one

分子式

C45H87NO5SSi3

熔点

密度

分子量

838.497

沸点

溶解度

信号词

危险品标志

若想填写更详细的询价信息，请点击进入询价页面

点我

化合物简介

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.

基本信息

中文名称

(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-1-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮

英文名称

(3S,7S,8S,12Z,15S,16E)-3,7,15-tris[[tert-butyl(dimethyl)silyl]oxy]-1-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadeca-12,16-dien-5-one

中文别名

英文别名

(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-1-HYDROXY-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)HEPTADECA-12,16-DIEN-5-ONE

CAS号

193146-53-1

分子式

C45H87NO5SSi3

分子量

838.497

精确质量

837.561

PSA

106.12

LOGP

13.7826

合成路线

共找到3条合成路线 >

(3S,6R,7S,8S,12Z,15S,16E)-1,3,7,15-四-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮

(3S,6R,7S,8S,12Z,15S,16E)-1,3,7,15-四-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮

(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-1-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮

(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-1-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮

上游原料

共找到49个上游原料 >

(2E)-2-Methyl-3-(2-methyl-1,3-thiazol-4-yl)acrylaldehyde

(2E)-2-Methyl-3-(2-methyl-1,3-thiazol-4-yl)acrylaldehyde

(2S,6Z,9S,10E)-9-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-11-(2-methyl-1,3-thiazol-4-yl)undeca-6,10-dienal

(2S,6Z,9S,10E)-9-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-11-(2-methyl-1,3-thiazol-4-yl)undeca-6,10-dienal

(3S)-3-methyl-1-phenylsulfonylbutan-4-ol

(3S)-3-methyl-1-phenylsulfonylbutan-4-ol

(5S)-5-hydroxy-4,4-dimethyloct-7en-3-one

(5S)-5-hydroxy-4,4-dimethyloct-7en-3-one

(3S)-3-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-5-oxo-heptanal

(3S)-3-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-5-oxo-heptanal

2,2-Dimethyl-3-oxopentanal

2,2-Dimethyl-3-oxopentanal

下游产品

共找到3个下游商品 >

(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)-5-氧代-十七-12,16-二烯酸

(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)-5-氧代-十七-12,16-二烯酸

埃博霉素B

Epothilone D

上游原料

(2E)-2-Methyl-3-(2-methyl-1,3-thiazol-4-yl)acrylaldehyde (2S,6Z,9S,10E)-9-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-11-(2-methyl-1,3-thiazol-4-yl)undeca-6,10-dienal (3S)-3-methyl-1-phenylsulfonylbutan-4-ol (5S)-5-hydroxy-4,4-dimethyloct-7en-3-one (3S)-3-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-5-oxo-heptanal 2,2-Dimethyl-3-oxopentanal (S,4Z,8E)-7-((tert-butyldimethylsilyl)oxy)-4,8-dimethyl-9-(2-methylthiazol-4-yl)nona-4,8-dien-1-ol methyl (S,2E,6E)-2-allyl-5-((tert-butyldimethylsilyl)oxy)-6-methyl-7-(2-methylthiazol-4-yl)hepta-2,6-dienoate (6Z,10E)-(2S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-2,6,10-trimethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dienenitrile 4-(氯甲基)-2-甲基-1,3-噻唑 (-)-(3S)-4-{[tert-butyl(diphenyl)silyl]oxy}-3-methylbutyl phenyl sulfone (-)-甲基(3S)-3,5-二-{[叔-丁基二甲基硅烷基)氧基]}-2,2-二甲基戊酸酯 (+)-甲基(3S)-5-{[叔-丁基二甲基硅烷基)氧基]}-3-羟基-2,2-二甲基戊酸酯 2-甲基-1,3-噻唑-4-甲醛 (5S)-5-{[(tert-butyl)dimethylsilyl]oxy}-7-hydroxy-4,4-dimethylheptan-3-one (1E)(3S)-3-(tert-butyl-dimethylsilyl)oxy-2-methyl-1-[2-methyl(1,3-thiazol-4-yl)]hexa-1,5-diene (S)-phenyl 5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-2,2-dimethylpentanoate 4-((1E,3S,5Z)-3-{[tert-butyl(dimethyl)silyl]oxy}-7-iodo-2,6-dimethylhepta-1,5-dienyl)-2-methyl-1,3-thiazole (3S,6R,7S,8S,12Z,15S,16E)-1,3,7,15-四-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮叔丁基二甲硅基三氟甲磺酸酯 2-甲基噻唑-4-甲酸乙酯 (5S)-5-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyloct-7en-3-one 1-{1-[(1E)-1-methyl-2-(2-methyl(1,3-thiazol-4-yl))vinyl](1S)(3Z)-4-methylhepta-3,6-dienyloxy}-1,1,2,2-tetramethyl-1-silapropane (3S,6R,7S,8S,12Z,15S,16E)-1,3,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-7-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七烷基-12,16-二烯-5-酮 (3S)-2-methyl-1-(2-methyl-1,3-thiazol-4-yl)hexa-1,5-dien-3-ol (2S,6Z,9S,10E)-9-((tert-butyldimethylsilyl)oxy)-N-((S)-2-(methoxymethyl)pyrrolidin-1-yl)-2,6,10-trimethyl-11-(2-methylthiazol-4-yl)undeca-6,10-dien-1-imine (2E,6E)(5S)-6-methyl-7-(2-methyl-(1,3-thiazol-4-yl))-2-prop-2-enyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)hepta-2,6-dien-1-ol (+)-(2S,6Z,9S,10E)-9-{[叔-丁基(二甲基)硅烷基]氧基}-2,6,10-三甲基-11-(2-甲基-1,3-噻唑-4-基)-十一碳-6,10-二烯-1-醇 (-)-(2Z,5S,6E)-5-{[叔-丁基(二甲基)硅烷基]氧基}-2,6-二甲基-7-(2-甲基-1,3-噻唑-4-基)庚-2,6-二烯-1-醇 (3S)-3-{[叔-丁基(二甲基)硅烷基]氧基}-5-羟基戊烷-2-酮 4-[(1E,3S,5Z,8R/S,10S)-3,11-二-{[叔-丁基(二甲基)硅烷基]氧基}-2,6,10-三甲基-8-(苯磺酰基)十一碳-1,5-二烯基]-2-甲基-1,3-噻唑 4-((S,1E,5Z)-3-((tert-butyldimethylsilyl)oxy)-9-iodo-2,6-dimethylnona-1,5-dien-1-yl)-2-methylthiazole (4S)-4,6-二-{[叔-丁基二甲基硅烷基)氧基]}-3,3-二甲基己烷-2-酮 (S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-pentanoic acid phenyl ester (5S)-5,7-二-{[叔-丁基二甲基硅烷基)氧基]}-4,4-二甲基庚烷-3-酮叔丁基二甲基氯硅烷 (-)-(3S,4E)-3-{[叔-丁基(二甲基)硅烷基]氧基}-4-甲基-5-(2-甲基-1,3-噻唑-4-基)戊-4-烯-1-醇 (3S)-4-{[叔-丁基(二甲基)硅烷基]氧基}-3-甲基丁基苯基砜 (S)-4-benzyl-3-((2S,6E,9S,10E)-9-((tert-butyldimethylsilyl)oxy)-6-(chloromethyl)-2,10-dimethyl-11-(2-methylthiazol-4-yl)undeca-6,10-dienoyl)oxazolidin-2-one (S)-4-benzyl-3-((S)-6-iodo-2-methylhept-6-enoyl)oxazolidin-2-one (4S)-4-benzyl-3-((2S,9S,E)-9-((tert-butyldimethylsilyl)oxy)-7-hydroxy-2,10-dimethyl-6-methylene-11-(2-methylthiazol-4-yl)undec-10-enoyl)oxazolidin-2-one (-)-(5S)-5,7-bis(tert-butyldimethylsilyloxy)-4,4-dimethylheptan-3-ol 3-[(叔丁基二甲基甲硅烷基)氧基]-1-丙醇乙基(2Z,5S,6E)-5-{[叔-丁基(二甲基)硅烷基]氧基}-2,6-二甲基-7-(2-甲基-1,3-噻唑-4-基)庚-2,6-二烯酸酯 (3S,4E)-3-{[tert-butyl(dimethyl)silyl]oxy}-4-methyl-5-(2-methyl-1,3-thiazol-4-yl)pent-4-en-1-al (-)-(3S)-3-{[叔-丁基(二甲基)硅烷基]氧基}二氢呋喃-2(3H)-酮 (4S,6E)-4-(tert-butyldimethylsilanyloxy)-5-methyl-6-(2-methyl-1,3-thiazol-4-yl)-5-hexene-1,2-diol 4-[(1E,3S,5Z,8R/S,10S)-3,11-二-{[叔-丁基(二甲基)硅烷基]氧基}-2,6,10-三甲基-十一碳-1,5-二烯基]-2-甲基-1,3-噻唑

下游产品

(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)-5-氧代-十七-12,16-二烯酸埃博霉素B Epothilone D