化合物简介
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
基本信息
中文名称
4-[(1E,3S,5Z,8R/S,10S)-3,11-二-{[叔-丁基(二甲基)硅烷基]氧基}-2,6,10-三甲基-8-(苯磺酰基)十一碳-1,5-二烯基]-2-甲基-1,3-噻唑
英文名称
4-[(1E,3S,5Z,10S)-3,11-Bis{[dimethyl(2-methyl-2-propanyl)silyl]ox y}-2,6,10-trimethyl-8-(phenylsulfonyl)-1,5-undecadien-1-yl]-2-met hyl-1,3-thiazole
中文别名
英文别名
4-[(1E,3S,5Z,8R/S,10S)-3,11-bis{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole、4-[(1-cyclopropylethyl)amino]-2-(trifluoromethyl)benzonitrile、Benzonitrile,4-[(1-cyclopropylethyl)amino]-2-(trifluoromethyl)
CAS号
308357-81-5
分子式
C36H61NO4S2Si2
分子量
692.175
精确质量
691.358
PSA
102.11
LOGP
11.943
物化性质
密度
1.027g/cm3
沸点
691.6ºC at 760 mmHg
闪点
372.1ºC
折射率
1.51
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