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洛那法尼

洛那法尼

CAS号：193275-84-2

英文名：LONAFARNIB

分子式

C27H31Br2ClN4O2

熔点

密度

1.536

分子量

638.822

沸点

710.4ºC at 760mmHg

溶解度

信号词

Warning

危险品标志

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化合物简介

Lonafarnib is a farnesyltransferase inhibitor (FTI) that is being investigated in a human clinical trial as a potential treatment for progeria.

基本信息

中文名称

洛那法尼

英文名称

LONAFARNIB

中文别名

克利贝特.环已双妥明、克利贝特、4-[2-[4-[(11R)-3,10-二溴-8-氯-6,11-二氢-5H-苯并[5,6]环庚并[1,2-b]吡啶-11-基]-1-哌啶基]-2-氧代乙基]-1-哌啶甲酰胺

英文别名

1-PiperidinecarboxaMide,4-[2-[4-[(11R)-3,10-dibroMo-8-chloro-6、4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide、4-{2-[4-(3,10-dibromo-8-chloro-6,l l-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide、4-[2-[4-[(11R)-3,10-DibroMo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1、[14C]-Lonafarnib、LonafarMib、Sarasar、Lonafarnib [usan]、(+)-4-[2-[4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]-pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyt]-1-piperidinecarboxamide

CAS号

193275-84-2

分子式

C27H31Br2ClN4O2

分子量

638.822

精确质量

636.05

PSA

79.53

LOGP

6.486

物化性质

密度

1.536

沸点

710.4ºC at 760mmHg

闪点

383.5ºC

安全信息

危险性防范说明

P305 + P351 + P338

危险性描述

H315; H319; H335

信号词

Warning

危险标志

GHS07

合成路线

三甲基硅基异氰酸酯

三甲基硅基异氰酸酯

(+)-4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11(R)-yl)-1-<(4-piperidinyl)acetyl>piperidine

(+)-4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11(R)-yl)-1-<(4-piperidinyl)acetyl>piperidine

洛那法尼

上游原料

共找到15个上游原料 >

4-[3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidine

4-[3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidine

(+)-1,1-dimethylethyl[[[4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-carbonyl]-methyl]-1-piperidinecarboxylate

(+)-1,1-dimethylethyl[[[4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-carbonyl]-methyl]-1-piperidinecarboxylate

3,10-dibromo-8-chloro-11-(piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

3,10-dibromo-8-chloro-11-(piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

三甲基硅基异氰酸酯

三甲基硅基异氰酸酯

上游原料

4-[3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidine 尿素 (+)-1,1-dimethylethyl[[[4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-carbonyl]-methyl]-1-piperidinecarboxylate 3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 三甲基硅基异氰酸酯 8-氯-3,10-二溴-5,6-二氢-11H-苯并[5,6]环庚烷并[1,2-B]吡啶 1-叔丁氧羰基-4-哌啶乙酸 4-[3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylic acid ethyl ester 4-(3-bromo-8-chloro-5,6-dihydro-9-nitro-11H-benzo-(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester (+)-4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11(R)-yl)-1-<(4-piperidinyl)acetyl>piperidine (R)-(+)-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidine 4-(3-bromo-8-chloro-5,6-dihydro-9-amino-11H-benzo-(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester 4-(8-chloro-3-bromo-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-1-carboxylic acid ethyl ester 4-<3,10-dibromo-8-chloro-5,6-dihydro-9-amino-11H-benzo-<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylic acid ethyl ester