化合物简介
Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii, is a non-specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. It displays a similar potency in vitro for the class I, II, and III PI3K members although it can also inhibit other PI3K-related enzymes such as mTOR, DNA-PKcs, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high concentrations , Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K. The half-life of wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI3K. Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation.
基本信息
中文名称
渥曼青霉素
英文名称
wortmannin
中文别名
奥特曼宁、抗生素SL-2052
英文别名
Wartmannin、SL-2052、Antibiotic SL-2052
CAS号
19545-26-7
分子式
C23H24O8
分子量
428.432
精确质量
428.147
PSA
109.11
LOGP
2.5364
编号系统
RTECS号
CB9641000
MDL号
MFCD00133927
EINECS号
214-538-0
BRN号
67676
PubChem号
24278777
物化性质
外观与性状
白色固体
密度
1.39 g/cm3
沸点
615.6ºC at 760 mmHg
熔点
234-240ºC
闪点
326.1ºC
折射率
1.591
储存条件
2-8ºC
蒸汽压
4.35E-15mmHg at 25°C
安全信息
安全说明
28-36/37-45
危险类别码
R26/27/28
危险品运输编码
UN 3462
危险品标志
T+
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