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奥司他韦
CAS号:196618-13-0
英文名:oseltamivir
分子式:C16H28N2O4
分子量:312.405
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合成路线
651324-04-8
ethyl (3R,4S,5R)-5-N-(1,1-dimethylethyl)amino-3-(1-ethylpropoxy)-4-hydroxy-1-cyclohexene-1-carboxylate
196618-13-0
奥司他韦
1132659-97-2
(3R,4S,5R)-4-[(diethoxyphosphoryl)amino]-3-(1-ethylpropoxy)-5-(methanesulfonyloxy)cyclohex-1-enecarboxylic acid ethyl ester
196618-13-0
奥司他韦
312904-11-3
ethyl (3R,4S,5R)-5-N-allyllamino-3-(1-ethylpropoxy)-4-hydroxy-1-cyclohexene-1-carboxylate
196618-13-0
奥司他韦
332047-17-3
ethyl (3R,4S,5R)-5-N-benzylideneamino-3-(1-ethylpropoxy)-4-hydroxy-1-cyclohexene-1-carboxylate
196618-13-0
奥司他韦
332047-18-4
ethyl (3R,4S,5R)-5-N-benzylideneamino-3-(1-ethylpropoxy)-4-methanesulfonyloxy-1-cyclohexene-1-carboxylate
196618-13-0
奥司他韦
1041262-69-4
(3R,4R,5S)-ethyl 5-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-4-(2-(trimethylsilyl)ethylsulfonamido)cyclohex-1-enecarboxylate
196618-13-0
奥司他韦
1041262-65-0
(1S,5S,6R)-ethyl 5-(1,3-dioxoisoindolin-2-yl)-7-(2-(trimethylsilyl)ethylsulfonyl)-7-aza-bicyclo[4.1.0]hept-2-ene-3-carboxylate
196618-13-0
奥司他韦
1402431-65-5
N-[1-nitro-4-oxo-3-(pentan-3-yloxy)butan-2-yl]acetamide
196618-13-0
奥司他韦
1041262-67-2
(3R,4R,5S)-ethyl 5-(1,3-dioxoisoindolin-2-yl)-3-(pentan-3-yloxy)-4-(N-(2-(trimethylsilyl)ethylsulfonyl)acetamido)cyclohex-1-enecarboxylate
196618-13-0
奥司他韦
1141364-92-2
(2R,3S)-tert-butyl 2-(nitromethyl)-4-oxo-3-(pentan-3-yloxy)butanoate
196618-13-0
奥司他韦
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上游原料
(R)-1-((3aS,4R,6S,6aS)-6-(benzyloxy)-2,2-diethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethane-1,2-diol
2,3:5,6-di-O-isopentylidene-α-D-mannofuranose
(3R,4R,5S)-4-amino-5-(tert-butoxycarbonylamino)-1-cyano-3-(1-ethylpropoxy)cyclohexene
5-叠氮奥塞米韦
(3R,4S,5R)-4-acetylamino-3-(1-ethyl-propoxy)-5-methanesulfonyloxy-cyclohex-1-enecarboxylic acid ethyl ester
ethyl (3R,4R,5S)-5-(1,3-dioxoisoindolin-2-yl)-3-(pentan-3-yloxy)-4-(acetamido)cyclohex-1-enecarboxylate
oseltamivir
(3aR,4S,7aS)-4-benzyloxycarbonylamino-3-tert-butoxycarbonylamino-6-cyano-3a,4,5,7a-tetrahydrobenzooxazol-2-one
(3R,4R,5S)-5-benzyloxycarbonylamino-4-tert-butoxycarbonylamino-1-cyano-3-hydroxycyclohexene
乙醇
ethyl (3R,4S,5R)-5-amino-3-(1-ethylpropoxy)-4-methanesulfonyloxy-1-cyclohexene-1-carboxylate
ethyl (3R,4R,5S)-5-N-allylamino-4-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
(3R,4R,5S)-ethyl 4-acetamido-5-(2-(hydroxymethyl)benzamido)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
ethyl (3R,4S,5R)-3-(1-ethylpropoxy)-5-N-formylamino-4-methanesulfonyloxy-1-cyclohexene-1-carboxylate
ethyl (3R,4R,5S)-4-acetamido-3-(pentan-3-yloxy)-5-((trimethyl-l5-phosphaneylidene)amino)cyclohex-1-ene-1-carboxylate
ethyl (3R,4R,5S)-4-acetamido-5-nitro-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
(3S,4R,5S)-5-(tert-butoxycarbonylamino)-3,4-(tert-butoxycarbonylimino)-1-cyanocyclohexene
(3aS,5R,6R,7R,7aS)-7-(1-ethylpropoxy)-6-hydroxy-2-oxooctahydrobenzooxazole-5-carboxylic acid ethyl ester
2-(pentan-3-yloxy)acetaldehyde
3-戊基甲烷磺酸酯
(3aS,4S,6R,6aS)-4-(benzyloxy)-6-((R)-2,2-diethyl-1,3-dioxolan-4-yl)-2,2-diethyltetrahydrofuro[3,4-d][1,3]dioxole
ethyl (3R,4R,5R,6R)-4-acetamido-5-azido-6-(methylsulfonyloxy)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
(3R,4R,5S)-4,5-bis(tert-butoxycarbonylamino)-1-cyano-3-(1-ethylpropoxy)cyclohexene
3-戊醇
tert-butyl [(1S,5R,6R)-6-acetylamino-3-cyano-5-(1-ethylpropoxy)cyclohex-3-en-1-yl]carbamate
ethyl 2-diethoxyphosphorylprop-2-enoate
ethyl (3R,4R,5R)-4-acetamido-3-(1-ethyl-propoxy)-5-hydroxy-cyclohex-1-ene-1-carboxylate
(3R,4R,5S)-5-benzyloxycarbonylamino-4-tert-butoxycarbonylamino-1-cyano-3-(1-ethylpropoxy)cyclohexene
(3R,4R,5S)-ethyl 4-acetylamino-3-(pentan-3-yloxy)-5-(2,2,2-trichloroacetamido)cyclohex-1-enecarboxylate
(1R,3S,4S,5S,6R)-5-(1-ethylpropoxy)-4,6-dihydroxycyclohexane-1,3-dicarboxylic acid 1-ethyl ester
(3S,4R,5S)-5-benzyloxycarbonylamino-4-tert-butoxycarbonylamino-1-cyano-3-hydroxycyclohexene
磷酸奥司他韦
(3aS,5R,6R,7R,7aS)-3-tert-butyl 5-ethyl 6-hydroxy-2-oxo-7-(pentan-3-yloxy)hexahydrobenzo[d]oxazole-3,5(2H)-dicarboxylate
2,6-二甲氧基苯酚
(3R,4R,5S)-ethyl-4-(N-acetylacetamide)-5-(1,3-dioxoisoindolin-2-yl)-3-(3-pentyloxy)cyclohex-1-ene carboxylate
1,5-dibromo-3-(1-ethylpropoxy)-2,4-dimethoxybenzene
all-cis-5-(1-ethylpropoxy)-4,6-dimethoxycyclohexane-1,3-dicarboxylic acid diethyl ester
5-(戊烷-3-基氧基)-7-氧代-双环[4.1.0]庚-3-烯-3-羧酸乙酯
5-(1-ethylpropoxy)-4,6-dimethoxyisophthalic acid diethyl ester
all-cis-5-(1-ethylpropoxy)-4,6-dihydroxycyclohexane-1,3-dicarboxylic acid diethyl ester
ethyl (3R,4S,5R)-5-N-formylamino-3-(1-ethylpropoxy)-4-hydroxy-1-cyclohexene-1-carboxylate
ethyl (3R,4R,5S)-4-N-acetylamino-5-N-allylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
(3S,4R,5S)-5-benzyloxycarbonylamino-3,4-tert-butoxycarbonylimino-1-cyanocyclohexene
(3aS,4S,6S,6aS)-6-(benzyloxy)-2,2-diethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbaldehyde
ethyl (3R,4S,5R)-5-amino-3-(1-ethylpropoxy)-4-hydroxy-1-cyclohexene-1-carboxylate
N-脱乙酰基5-叠氮基奥塞米韦
D-甘露糖
(1S,2R,3S,4R,5S)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate
下游产品
磷酸奥司他韦