百科

(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

CAS号：197233-36-6

英文名：(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

分子式：C53H75NO5SSi2

分子量：894.402

合成路线

184297-50-5

(1R,3S,4S,5R,6R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-4,6-dimethyl-2-oxa-bicyclo[4.1.0]heptan-5-ol

197233-36-6

(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

197233-43-5

(6S,7S,8R,9R)-7-(tert-Butyl-dimethyl-silanyloxy)-10-[1,3]dithian-2-yl-2,6,8,10-tetramethyl-9-triphenylsilanyloxy-undec-1-en-5-ol

197233-36-6

(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

197233-11-7

[(4R,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-yloxy]-triphenyl-silane

197233-36-6

(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

197233-10-6

(4R,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-ol

197233-36-6

(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

186692-74-0

(2S,3S,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-[1,3]dithian-2-yl-2,4,6-trimethyl-5-triphenylsilanyloxy-heptan-1-ol

197233-36-6

(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

上游原料

[(4R,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-yloxy]-triphenyl-silane (2S,3S,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-[1,3]dithian-2-yl-2,4,6-trimethyl-5-triphenylsilanyloxy-heptan-1-ol (1R,3S,4S,5R,6R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-4,6-dimethyl-2-oxa-bicyclo[4.1.0]heptan-5-ol (6S,7S,8R,9R)-7-(tert-Butyl-dimethyl-silanyloxy)-10-[1,3]dithian-2-yl-2,6,8,10-tetramethyl-9-triphenylsilanyloxy-undec-1-en-5-ol (4R,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-ol

下游产品

埃博霉素B (1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8,12-pentamethyl-5-oxo-12-tridecenoate Epothilone D