百科

(1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8,12-pentamethyl-5-oxo-12-tridecenoate

CAS号：197233-39-9

英文名：(1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8,12-pentamethyl-5-oxo-12-tridecenoate

分子式：C41H73NO5SSi2

分子量：748.258

合成路线

204195-22-2

(4S)-4-isopropyl-3-(6-methyl-hept-6-enoyl)-oxazolidin-2-one

197233-39-9

(1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8,12-pentamethyl-5-oxo-12-tridecenoate

130199-57-4

L-threo-Pentitol, 3,4-anhydro-2-deoxy-2,2-dimethyl-1-O-(phenylmethyl)-

197233-39-9

(1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8,12-pentamethyl-5-oxo-12-tridecenoate

197233-36-6

(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

197233-39-9

(1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8,12-pentamethyl-5-oxo-12-tridecenoate

212508-16-2

(3S,5R,6S,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-(4-methoxy-benzyloxy)-4,4,6,8,12-pentamethyl-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester

197233-39-9

(1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8,12-pentamethyl-5-oxo-12-tridecenoate

210690-75-8

(4S)-4-[(E)-2-Ethyl-1,1-dimethyl-2-butenyl]-2,2-dimethyl-1,3-dioxane

197233-39-9

(1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8,12-pentamethyl-5-oxo-12-tridecenoate

97344-88-2

isopentenylmagnesium bromide

197233-39-9

(1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8,12-pentamethyl-5-oxo-12-tridecenoate

上游原料

(3R,5R,6R,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,6,8,12-pentamethyl-5-triphenylsilanyloxy-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester isopentenylmagnesium bromide (4S)-4-[(E)-2-Ethyl-1,1-dimethyl-2-butenyl]-2,2-dimethyl-1,3-dioxane (3S,5R,6S,7S,8S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-(4-methoxy-benzyloxy)-4,4,6,8,12-pentamethyl-tridec-12-enoic acid (S)-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester (4S)-4-isopropyl-3-(6-methyl-hept-6-enoyl)-oxazolidin-2-one

下游产品

(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,12-pentamethyl-5-oxo-tridec-12-enoic acid methyl ester (S)-14-methyl-epothilone D (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,12-pentamethyl-5-oxo-tridec-12-enoic acid (S)-1-(2-methyl-benzooxazol-5-yl)-but-3-enyl ester (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,12-pentamethyl-5-oxo-tridec-12-enoic acid (1S,2S)-2-methyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-but-3-enyl ester