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1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇

1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇

CAS号：198481-32-2

英文名：1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

分子式

C30H34N2O3

熔点

密度

1.19g/cm3

分子量

470.603

沸点

694.4ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. In late 2013, Pfizer received approval for bazedoxifene as part of the combination drug DUAVEE in the prevention (not treatment) of postmenopausal osteoporosis. Bazedoxfiene is the result of an exclusive research collaboration between Wyeth Pharmaceuticals and Ligand Pharmaceuticals.

基本信息

中文名称

1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇

英文名称

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol

中文别名

巴多昔芬

英文别名

TSE-424、bazedoxifene、Conbriza、Bazedoxifeno

CAS号

198481-32-2

分子式

C30H34N2O3

分子量

470.603

精确质量

470.257

PSA

57.86

LOGP

6.2689

编号系统

UNII

Q16TT9C5BK

物化性质

密度

1.19g/cm3

沸点

694.4ºC at 760 mmHg

闪点

373.8ºC

折射率

1.622

蒸汽压

6.33E-20mmHg at 25°C

合成路线

5-苄氧基-2-(4-苄氧基-苯基)-3-甲基-1-[4-(2-氮杂环庚烷-1-基-乙氧基)-苄基]-1H-吲哚

5-苄氧基-2-(4-苄氧基-苯基)-3-甲基-1-[4-(2-氮杂环庚烷-1-基-乙氧基)-苄基]-1H-吲哚

1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇

1-[[4-[2-(氮杂环庚烷-1-基)乙氧基]苯基]甲基]-2-(4-羟基苯基)-3-甲基-吲哚-5-醇

上游原料

共找到32个上游原料 >

p-(2-(tosyloxy)ethoxy)benzaldehyde

p-(2-(tosyloxy)ethoxy)benzaldehyde

1-(2-(4-(氯甲基)苯氧基)乙基)氮杂䓬盐酸盐

1-(2-(4-(氯甲基)苯氧基)乙基)氮杂䓬盐酸盐

对羟基苯丙酮

对羟基苯丙酮

1-(2-{4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-ethyl)-azepane-2,7-dione

1-(2-{4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-ethyl)-azepane-2,7-dione

{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile

{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile

2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl 4-methylbenzene-1-sulfonate

2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl 4-methylbenzene-1-sulfonate

上游原料

p-(2-(tosyloxy)ethoxy)benzaldehyde 1-(2-(4-(氯甲基)苯氧基)乙基)氮杂䓬盐酸盐对羟基苯丙酮 1-(2-{4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-ethyl)-azepane-2,7-dione {4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile 2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl 4-methylbenzene-1-sulfonate 1-[4-(2-Amino-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol 2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl methanesulfonate 2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethanol 2-(环己亚氨基)乙基氯 2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl benzenesulfonate 对羟基苯甲醇 (4-氯甲基苯氧基)-乙酸乙酯 5-苄氧基-2-(4-苄氧基-苯基)-3-甲基-1-[4-(2-氮杂环庚烷-1-基-乙氧基)-苄基]-1H-吲哚 1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-3-methyl-2-(4-(phosphonooxy)phenyl)-1H-indol-5-yl dihydrogen phosphate (4-hydroxymethylphenoxy)acetonitrile (4-(2-(氮杂环庚烷-1-基)乙氧基)苯基)甲醇 4-(2-羟基乙氧基)苯甲醛 4'-苄氧基苯丙酮 2-[4-(chloromethyl)phenoxy]acetonitrile 4’-苯甲氧基-2-溴苯丙酮 ethyl 2-[4-[[3-methyl-5-phenylmethoxy-2-(4-phenylmethoxyphenyl)indol-1-yl]methyl]phenoxy]acetate 2-(4-(羟基甲基)苯氧基)乙酸乙酯 2-(4-bromomethylphenoxy)ethyl 4-methylbenzenesulfonate 5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole 3-甲基-5-苄氧基-2-(4-苄氧基苯基)-1H-吲哚己二醛高哌啶 4-苯甲氧基苯胺盐酸盐 adipic acid anhydride