化合物简介
(3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-Dimethylethyl ester is used as a reagent in the synthesis of abeo-taxane derivatives that possess broad inhibitory effects against proliferation of colon cancer, melanoma, and renal cancer cell lines. (3R,4S)-3-(1-Ethoxyethoxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 1,1-Dimethylethyl ester is also used as a reagent in the synthesis of a novel D-ring modified Docetaxel analogue which has proven to have equipotent cytotoxicity in relation to Paclitaxel towards cancer cell lines.
基本信息
中文名称
(3R,4S)-3-(1-乙氧乙氧基)-2-氧-4-苯基-吖丁啶羧酸叔丁基酯
英文名称
tert-butyl (3R,4S)-3-(1-ethoxyethoxy)-2-oxo-4-phenylazetidine-1-carboxylate
中文别名
(3R,4S)-1-叔丁氧基羰基-3-(2-乙氧乙氧基)-4-苯基-2-丙内酰胺、(3R,4S)-1-叔丁氧基羰基-3-(1-乙氧基乙氧基)-4-苯基-2-氮杂环丁酮
英文别名
CAS号
201856-57-7
分子式
C18H25NO5
分子量
335.395
精确质量
335.173
PSA
65.07
LOGP
3.2106
物化性质
密度
1.16
沸点
459.6ºC at 760 mmHg
闪点
231.8ºC
折射率
1.532
蒸汽压
1.25E-08mmHg at 25°C
合成路线