化合物简介
Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability.
基本信息
中文名称
4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉
英文名称
Janex 1
中文别名
英文别名
1-Amino-4-<4-hydroxy-anilino>-anthrachinon-2-sulfonsaeure
CAS号
202475-60-3
分子式
C16H15N3O3
分子量
297.309
精确质量
297.111
PSA
76.5
LOGP
3.1692
编号系统
MDL号
MFCD01862614