百科

(E)-3'-O-Acetyl-5'-{3-[(3'R)-3-benzyloxymethyl-5'-O-(tert-butyldimethylsilyl)-3'-deoxythymidin-3'-yl]-2-oxopropylidene}-5'-deoxythymidine

(E)-3'-O-Acetyl-5'-{3-[(3'R)-3-benzyloxymethyl-5'-O-(tert-butyldimethylsilyl)-3'-deoxythymidin-3'-yl]-2-oxopropylidene}-5'-deoxythymidine

CAS号：202719-38-8

英文名：(E)-3'-O-Acetyl-5'-{3-[(3'R)-3-benzyloxymethyl-5'-O-(tert-butyldimethylsilyl)-3'-deoxythymidin-3'-yl]-2-oxopropylidene}-5'-deoxythymidine

分子式：C39H52N4O11Si

分子量：780.936

合成路线

1-[(2R,4S,5S)-4-Allyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-3-benzyloxymethyl-5-methyl-1H-pyrimidine-2,4-dione

1-[(2R,4S,5S)-4-Allyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-3-benzyloxymethyl-5-methyl-1H-pyrimidine-2,4-dione

(E)-3'-O-Acetyl-5'-{3-[(3'R)-3-benzyloxymethyl-5'-O-(tert-butyldimethylsilyl)-3'-deoxythymidin-3'-yl]-2-oxopropylidene}-5'-deoxythymidine

(E)-3'-O-Acetyl-5'-{3-[(3'R)-3-benzyloxymethyl-5'-O-(tert-butyldimethylsilyl)-3'-deoxythymidin-3'-yl]-2-oxopropylidene}-5'-deoxythymidine

3-Benzyloxymethyl-1-[(2R,4R,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-(2-imidazol-1-yl-2-oxo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

3-Benzyloxymethyl-1-[(2R,4R,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-(2-imidazol-1-yl-2-oxo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

(E)-3'-O-Acetyl-5'-{3-[(3'R)-3-benzyloxymethyl-5'-O-(tert-butyldimethylsilyl)-3'-deoxythymidin-3'-yl]-2-oxopropylidene}-5'-deoxythymidine

(E)-3'-O-Acetyl-5'-{3-[(3'R)-3-benzyloxymethyl-5'-O-(tert-butyldimethylsilyl)-3'-deoxythymidin-3'-yl]-2-oxopropylidene}-5'-deoxythymidine

上游原料

3-Benzyloxymethyl-1-[(2R,4R,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-4-(2-imidazol-1-yl-2-oxo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 1-[(2R,4S,5S)-4-Allyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-3-benzyloxymethyl-5-methyl-1H-pyrimidine-2,4-dione

下游产品

Acetic acid (2R,3S,5R)-2-{4-[(2S,3R,5R)-2-formyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-oxo-butyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 5'-{3-[(3'R)-5'-(4,4'-Dimethoxytrityl)-3'-deoxythymidin-3'-yl]-2-oxopropyl}-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-deoxythymidine 5'-{3-[(3'R)-5'-(4,4'-Dimethoxytrityl)-3'-deoxythymidin-3'-yl]-2-oxopropyl}-5'-deoxythymidine 3'-O-Acetyl-5'-{3-[(3'R)-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-yl]-2-oxopropyl}-5'-deoxythymidine 2-Cyanoethyl {5'-[3-((3'R)-3'-deoxythymidin-3'-yl)-2-oxopropyl]-5'-deoxythymidin-3'-yl}(3'-acetylthymidin-5'-O-yl)phosphinate