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5,25R-胆甾烯-3beta,26-二醇

5,25R-胆甾烯-3beta,26-二醇

CAS号:20380-11-4
英文名:(25R)-cholest-5-ene-3β,26-diol
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化合物简介
27-Hydroxycholesterol (27-HC) is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.
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物化性质
下游产品
(25R)-3-oxo-5α-cholestan-26-oic acid (8S,9S,10R,13R,14S,17R)-17-[(1R,5R)-6-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one (25R)-7-oxocholest-5-en-3β,26-diyl dibenzoate (25R)-3β-(tert-butyldimethylsilyloxy)-4,4-dimethyl-26-chloro-cholest-5,7-diene (25R)-26-(tert-butyldimethylsilyloxy)cholest-5-en-3β-ol 2,2-Dimethyl-propionic acid (2R,6R)-6-{(3R,5S,8R,9S,10S,13R,14S,17R)-3-[2-(4-benzoyl-phenyl)-acetoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-2-methyl-heptyl ester Toluene-4-sulfonic acid (2R,6R)-6-[(3S,9S,10R,13R,14R,17R)-3-(tert-butyl-dimethyl-silanyloxy)-4,4,10,13-tetramethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester (8S,9S,10R,13R,14S,17R)-17-[(1R,5R)-6-(tert-Butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-4,4,10,13-tetramethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one (25R)-26-iodo-4,4-dimethyl-5α-cholesta-8,14-dien-3β-ol 3-(tert-butyl-dimethyl-silanyloxy)-17-[6-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-4,4,10,13-tetramethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene 3β-(25R)-26-bis(tert-butyldimethylsilyloxy)4,4-dimethylcholest-5,7-diene (25R)-5α-cholestane-3β,26-diol 26-pivalate 3β-hydroxy-4,4-dimethyl-(25R)-26-(tert-butyldimethylsilyloxy)cholest-5-ene (25S)-3β-acetoxy-26-trityloxycholest-5-ene (25R)-5α-cholest-14-ene-3α,26-diol 3α,26-diacetate 3-O-acetyl-26-hydroxy-26-O-tosylcholesterol (25R)-26-chloro-4,4-dimethyl-5α-cholesta-8,14-dien-3β-ol tert-Butyl-[(3S,9S,10R,13R,14R,17R)-17-((R)-1,5-dimethyl-hex-5-enyl)-4,4,10,13-tetramethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-dimethyl-silane (25R)-cholest-5-ene-3β,7α,26-triol 3β,26-dibenzoate (25R)-(26-tosyloxy)-4,4-dimethyl-5α-cholesta-8,14-diene-3β-ol (25R)-26-acetoxy-3β-(tert-butyldimethylsilyloxy)cholest-5-ene