百科

(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

CAS号：213408-74-3

英文名：(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

分子式：C42H76O7Si2

分子量：749.22

合成路线

(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-8,10-bis((diethyl(isopropyl)silyl)oxy)-9-ethyl-18-((S)-1-hydroxypropan-2-yl)-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one

(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-8,10-bis((diethyl(isopropyl)silyl)oxy)-9-ethyl-18-((S)-1-hydroxypropan-2-yl)-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one

(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

(2R,3R,4S,5S,6R)-4-ethyl-3,5-dihydroxy-2,6-dimethylnon-8-yn-1-yl pivalate

(2R,3R,4S,5S,6R)-4-ethyl-3,5-dihydroxy-2,6-dimethylnon-8-yn-1-yl pivalate

(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

1-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

1-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol

(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

(2S)-2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)butan-1-ol

(2S)-2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)butan-1-ol

(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

(R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal

上游原料

(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-8,10-bis((diethyl(isopropyl)silyl)oxy)-9-ethyl-18-((S)-1-hydroxypropan-2-yl)-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one (2R,3R,4S,5S,6R)-4-ethyl-3,5-dihydroxy-2,6-dimethylnon-8-yn-1-yl pivalate 1-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)propan-1-ol (2S)-2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)butan-1-ol

下游产品

(3E,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-二羟基-5-甲基-6-[(E)-丙-1-烯基]四氢吡喃-2-基]-3-羟基戊烷-2-基]-9-乙基-8,10-二羟基-3,17-二甲氧基-5,7,11,13-四甲基-1-氧杂环十八碳-3,5,13,15-四烯-2-酮