伊沙匹隆

伊沙匹隆

CAS号：219989-84-1

英文名：ixabepilone

分子式

C27H42N2O5S

熔点

密度

1.122g/cm3

分子量

506.698

沸点

697.8ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Ixabepilone is an anti-tumor agent used in the treatment of patients suffering from solid tumors, such as metastatic breast cancer.

基本信息

中文名称

伊沙匹隆

英文名称

ixabepilone

中文别名

英文别名

Ixempra、[1S-[1R*,3R*(E),7R*,10S*,11R*,12R*,16S*]]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4-aza-17-oxabicyclo[14.1.0]heptadecane-5,9-dione、16-aza-epothilone B、Ixabepilone、(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-methyl-2-(2-methylthiazol-4-yl)vinyl]-17-oxa-4-azabicyclo[14.1.0]hepta-decane-5,9-dione、15-aza-EpoB、Azaepothilone B、Ixabepilone [INN]、[14C]-Ixabepilone、(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione

CAS号

219989-84-1

分子式

C27H42N2O5S

分子量

506.698

精确质量

506.281

PSA

140.29

LOGP

4.3793

物化性质

密度

1.122g/cm3

沸点

697.8ºC at 760mmHg

闪点

375.8ºC

折射率

1.532

蒸汽压

1.93E-20mmHg at 25°C

合成路线

(3S,6R,7S,8S,12R,13S,15S)-15-amino-12,13-epoxy-4,4,6,8,12,16-hexamethyl-3,7-dihydroxy-17-(2-methyl-4-thiazolyl)-5-oxo-16(E)-heptadecenoic acid

(3S,6R,7S,8S,12R,13S,15S)-15-amino-12,13-epoxy-4,4,6,8,12,16-hexamethyl-3,7-dihydroxy-17-(2-methyl-4-thiazolyl)-5-oxo-16(E)-heptadecenoic acid

伊沙匹隆

上游原料

共找到15个上游原料 >

tert-butyl (2Z,6R,7S,8S,12Z,15S,16E)-15-azido-3-methoxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-2,12,16-trienoate

tert-butyl (2Z,6R,7S,8S,12Z,15S,16E)-15-azido-3-methoxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-2,12,16-trienoate

tert-butyl (2Z,6R,7S,8S,12Z,15S,16E)-15-amino-3-methoxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-2,12,16-trienoate

tert-butyl (2Z,6R,7S,8S,12Z,15S,16E)-15-amino-3-methoxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-2,12,16-trienoate

(Z)-(6R,7S,8S)-3-Methoxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloro-ethoxycarbonyloxy)-undeca-2,10-dienoic acid tert-butyl ester

(Z)-(6R,7S,8S)-3-Methoxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloro-ethoxycarbonyloxy)-undeca-2,10-dienoic acid tert-butyl ester

tert-butyl (6R,7S,8S,12Z,15S,16E)-15-((tert-butoxycarbonyl)amino)-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-3,5-dioxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-12,16-dienoate

tert-butyl (6R,7S,8S,12Z,15S,16E)-15-((tert-butoxycarbonyl)amino)-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-3,5-dioxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-12,16-dienoate

tert-butyl (3S,6R,7S,8S,12Z,15S,16E)-15-((tert-butoxycarbonyl)amino)-3-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-12,16-dienoate

tert-butyl (3S,6R,7S,8S,12Z,15S,16E)-15-((tert-butoxycarbonyl)amino)-3-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-12,16-dienoate

(4S,7R,8S,9S,16S,Z)-4-hydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-2,6-dioxoazacyclohexadec-13-en-8-yl (2,2,2-trichloroethyl) carbonate

(4S,7R,8S,9S,16S,Z)-4-hydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-2,6-dioxoazacyclohexadec-13-en-8-yl (2,2,2-trichloroethyl) carbonate

上游原料

tert-butyl (2Z,6R,7S,8S,12Z,15S,16E)-15-azido-3-methoxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-2,12,16-trienoate tert-butyl (2Z,6R,7S,8S,12Z,15S,16E)-15-amino-3-methoxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-2,12,16-trienoate (Z)-(6R,7S,8S)-3-Methoxy-4,4,6,8-tetramethyl-5-oxo-7-(2,2,2-trichloro-ethoxycarbonyloxy)-undeca-2,10-dienoic acid tert-butyl ester tert-butyl (6R,7S,8S,12Z,15S,16E)-15-((tert-butoxycarbonyl)amino)-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-3,5-dioxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-12,16-dienoate tert-butyl (3S,6R,7S,8S,12Z,15S,16E)-15-((tert-butoxycarbonyl)amino)-3-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-12,16-dienoate (4S,7R,8S,9S,16S,Z)-4-hydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-2,6-dioxoazacyclohexadec-13-en-8-yl (2,2,2-trichloroethyl) carbonate tert-butyl (2Z,6R,7S,8S,12Z,15S,16E)-15-((tert-butoxycarbonyl)amino)-3-methoxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-2,12,16-trienoate (5R)-5-hydroxy-2-iodo-6-methyl-7-(2-methylthiazol-4-yl)-2,6-heptadiene (3S,6R,7S,8S,12Z,15S,16E)-15-amino-3-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-5-oxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-12,16-dienoic acid (5S)-5-azido-2-iodo-6-methyl-7-(2-methylthiazol-4-yl)-2,6-heptadiene (3S,6R,7S,8S,12R,13S,15S)-15-amino-12,13-epoxy-4,4,6,8,12,16-hexamethyl-3,7-dihydroxy-17-(2-methyl-4-thiazolyl)-5-oxo-16(E)-heptadecenoic acid (3S,6R,7S,8S,12R,13S,15S)-15-azido-12,13-epoxy-4,4,6,8,12,16-hexamethyl-3,7-dihydroxy-17-(2-methyl-4-thiazolyl)-5-oxo-16(E)-heptadecenoic acid 埃博霉素B (3S,6R,7S,8S)-11-((2R,3S)-3-((S,E)-2-(2-acetylhydrazinyl)-3-methyl-4-(2-methylthiazol-4-yl)but-3-en-1-yl)-2-methyloxiran-2-yl)-3,7-dihydroxy-4,4,6,8-tetramethyl-5-oxoundecanoic acid [4S-[4R*,7S*,8R*,9R*,15R*(E)]]-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-1-aza-13(Z)-cyclohexadecene-2,6-dione