化合物简介
Carboxycyclophosphamide is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide. In the metabolic pathway of cyclophosphamide inactivation it first metabolizes to 4-hydroxycyclophosphamide, then partially tautomerizes into aldophosphamide. Aldophosphamide then, in turn, is oxidized into carboxycyclophosphamide by the enzyme ALDH (aldehyde dehydrogenase).
基本信息
中文名称
羧基磷酰胺
英文名称
3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid
中文别名
英文别名
Carboxyphosphamide、Carboxyphosphamid、2-Carboxyethyl-N,N-bis(2-chloroethyl)phosphorodiamidate、N,N-Bis-(2-chlorethyl)-diamidophosphorsaeure-(2-carboxyethylester) (freie Saeure)、Carboxycyclophosphamide、Asta 5754、carboxyethylphosphoramide mustard、Hydracrylic acid,N,N-bis(2-chloroethyl)phosphorodiamidate、O-carboxyethylphosphoramide mustard、O-(2-Carboxyethyl) N,N-bis(2-chloroethyl)phosphorodiamidate
CAS号
22788-18-7
分子式
C7H15Cl2N2O4P
分子量
293.085
精确质量
292.015
PSA
102.67
LOGP
2.0244
编号系统
UNII
DP4677AX41
物化性质
密度
1.444g/cm3
沸点
447.4ºC at 760mmHg
闪点
224.3ºC
折射率
1.519
蒸汽压
2.99E-09mmHg at 25°C
安全信息
海关编码
2931900090
合成路线
