百科

茴香霉素

茴香霉素

CAS号：22862-76-6

英文名：(-)-anisomycin

分子式

C14H19NO4

熔点

140-141ºC

密度

1.21 g/cm3

分子量

265.305

沸点

398.7ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Anisomycin, also known as flagecidin, is an antibiotic produced by Streptomyces griseolus which inhibits eukaryotic protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.

基本信息

中文名称

茴香霉素

英文名称

(-)-anisomycin

中文别名

英文别名

Anisomycin from Streptomyces griseolus、ANISOMYCIN,STREPTOMYCES GRISEOLUS、ANISOMYCIN FROM STREPTOMYCES GRISEOLUS、FLAGECIDIN、Anisomycin,(2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol3-acetate、antibioticpa-106、(2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol 3-Acetate、2-p-methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine

CAS号

22862-76-6

分子式

C14H19NO4

分子量

265.305

精确质量

265.131

PSA

67.79

LOGP

0.8309

编号系统

MDL号

MFCD00077650

PubChem号

24891496

EINECS号

245-269-7

RTECS号

BZ9800000

BRN号

20705

物化性质

外观与性状

白色结晶固体

密度

1.21 g/cm3

沸点

398.7ºC at 760 mmHg

熔点

140-141ºC

闪点

194.9ºC

稳定性

Stable. Incompatible with strong oxidizing agents.

储存条件

库房通风低温干燥,与食品原料分开存放

蒸汽压

0mmHg at 25°C

安全信息

安全说明

45-36-26

危险类别码

R25

海关编码

2933990090

危险品运输编码

UN 3462 6

危险类别

6.1(b)

包装等级

III

危险品标志

T

生产方法及用途

用途

用于豆科植物霉病的根除,抑制植物中病理霉菌的生长。

合成路线

(2R,3S,4S)-3-acetoxy-N-(benzyloxycarbonyl)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidine

(2R,3S,4S)-3-acetoxy-N-(benzyloxycarbonyl)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidine

茴香霉素

上游原料

共找到45个上游原料 >

(2R,3S,4S)-3-Acetoxy-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzyl)pyrrolidine

(2R,3S,4S)-3-Acetoxy-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzyl)pyrrolidine

N-(adamantan-1-ylmethyl)-N,N-dimethyldecan-1-aminium bromide

N-(adamantan-1-ylmethyl)-N,N-dimethyldecan-1-aminium bromide

(2R,3S,4S)-1-(tert-Butoxycarbonyl)-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine

(2R,3S,4S)-1-(tert-Butoxycarbonyl)-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine

(2R,3S,4R)-3,4-dihydroxy-2-(p-methoxybenzyl)pyrrolidine hydrochloride

(2R,3S,4R)-3,4-dihydroxy-2-(p-methoxybenzyl)pyrrolidine hydrochloride

(3R,4R)-4-azido-5-(4-methoxyphenyl)pent-1-en-3-ol

(3R,4R)-4-azido-5-(4-methoxyphenyl)pent-1-en-3-ol

(E,Z)-5-deoxy-2,3-O-isopropylidene-5-(p-methoxyphenyl)-L-ribose oxime

(E,Z)-5-deoxy-2,3-O-isopropylidene-5-(p-methoxyphenyl)-L-ribose oxime

上游原料

(2R,3S,4S)-3-Acetoxy-1-(tert-butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzyl)pyrrolidine N-(adamantan-1-ylmethyl)-N,N-dimethyldecan-1-aminium bromide (2R,3S,4S)-1-(tert-Butoxycarbonyl)-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine (2R,3S,4R)-3,4-dihydroxy-2-(p-methoxybenzyl)pyrrolidine hydrochloride (3R,4R)-4-azido-5-(4-methoxyphenyl)pent-1-en-3-ol (E,Z)-5-deoxy-2,3-O-isopropylidene-5-(p-methoxyphenyl)-L-ribose oxime N-乙酰基-O-甲基-L-酪氨酸甲酯 N-乙酰-D-酪氨酸 (2R,3S,4R)-3,4-epoxy-2-(p-methoxybenzyl)pyrrolidine (2S,3S,4R)-4-amino-5-(4-methoxyphenyl)pentane-1,2,3-triol (3S,4S)-trimethylsilyloxy oxirane (2R,3S,4R)-3,4-isopropylidenedioxy-2-(p-methoxybenzyl)-pyrrolidine 1-deoxy-3,4-O-isopropylidene-1-(p-methoxyphenyl)-D-allitol (4R,5S,6S)-5-(tert-butyldimethylsilyloxy)-4-(4-methoxybenzyl)-2-phenyl-6-vinyl-5,6-dihydro-4H-1,3-oxazine (2S,3S)-pentene-1,2,3-triol 5-deoxy-2,3-O-isopropylidene-4-O-methylsulphonyl-5-(p-methoxyphenyl)-L-ribononitrile 5-deoxy-2,3-O-isopropylidene-5-(p-methoxyphenyl)-β-L-ribofuranose tert-butyl ((2R,3S,4S)-3,4,5-trihydroxy-1-(4-methoxyphenyl)pentan-2-yl)carbamate (2S,3R)-1-(4-Methoxy-phenyl)-3-trimethylsilanyloxy-pent-4-en-2-ol (2R,3S,4S)-4-allyloxy-3-hydroxy-2-(p-methoxybenzyl)-pyrrolidine (4R,5S)-4-(4-methoxybenzyl)-2-methyl-5-((S)-oxiran-2-yl)-4,5-dihydrooxazole tert-butyl ((2S,3S,4S)-3,4,5-trihydroxy-1-iodopentan-2-yl)carbamate (1S,2R)-2-azido-3-(4-methoxyphenyl)-1-((S)-oxiran-2-yl)propyl acetate 2,2,2-Trichloro-acetimidic acid (1S,2S)-2-(2,2,2-trichloro-acetimidoyloxy)-1-(2,2,2-trichloro-acetimidoyloxymethyl)-but-3-enyl ester (4R,5S,6S)-4-(4-methoxybenzyl)-2-phenyl-6-vinyl-5,6-dihydro-4H-1,3-oxazin-5-ol tert-butyl (2R,3S,4S)-3-acetoxy-4-hydroxy-2-(4-methoxybenzyl)pyrrolidine-1-carboxylate (4R,5S,6S)-4-(4-methoxybenzyl)-2-phenyl-6-vinyl-5,6-dihydro-4H-1,3-oxazin-5-yl acetate (2R,3S,4S)-2-((tert-butoxycarbonyl)amino)-4,5-dihydroxy-1-(4-methoxyphenyl)pentan-3-yl acetate (R,Z)-N-(5-hydroxy-1-(4-methoxyphenyl)pent-3-en-2-yl)acetamide (2R,3S,4R)-2-azido-5-bromo-4-hydroxy-1-(4-methoxyphenyl)pentan-3-yl acetate 4-甲氧基氯苄 (2R,3S,4S)-1-(tert-Butoxycarbonyl)-4-(tert-butyldimethylsilyloxy)-3-hydroxy-2-(4-methoxybenzyl)pyrrolidine 4-甲氧苄基氯化镁 1,4-戊二烯-3-醇 (1R)-1-[(2S)-oxiran-2-yl]prop-2-en-1-ol (2S,3R)-1-(4-methoxyphenyl)-3-((trimethylsilyl)oxy)pent-4-en-2-yl methanesulfonate (2R,3S,4S)-3-acetoxy-N-(benzyloxycarbonyl)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidine D-酪氨酸