化合物简介
Lofepramine (brand name: Lomont (UK) Emdalen (ZA), Gamanil (IE, UK (discontinued)) & Tymelyt (discontinued)) is a third generation tricyclic antidepressant which was introduced in 1983 for the treatment of depressive disorders. Lofepramine is less sedating than, for instance, amitriptyline, and is safer in overdose than older tricyclics.
基本信息
中文名称
洛非帕明
英文名称
lofepramine
中文别名
氯苯咪嗪
英文别名
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone、Lofepramine
CAS号
23047-25-8
分子式
C26H27ClN2O
分子量
418.958
精确质量
418.181
PSA
23.55
LOGP
5.8465
编号系统
UNII
OCA4JT7PAW
物化性质
密度
1.173g/cm3
沸点
575ºC at 760mmHg
闪点
301.6ºC
折射率
1.607
蒸汽压
3.17E-13mmHg at 25°C
