化合物简介
Dapivirine (TMC120) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) developed at Janssen Therapeutics (formerly Tibotec Therapeutics). The International Partnership for Microbicides (IPM) has held exclusive worldwide rights to dapivirine since 2014, building upon a 2004 royalty-free license to develop dapivirine-based microbicides for women in resource-poor countries.
基本信息
中文名称
Dapivirine
英文名称
4-[[4-(2,4,6-trimethylanilino)pyrimidin-2-yl]amino]benzonitrile
中文别名
英文别名
4-({4-[(2,4,6-trimethylphenyl)amino]pyrimidin-2-yl}amino)benzenecarbonitrile、UNII-TCN4MG2VXS、4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile、dapivirinum、Dapivirine (TMC120)、Dapivirine、TMC120
CAS号
244767-67-7
分子式
C20H19N5
分子量
329.398
精确质量
329.164
PSA
73.63
LOGP
4.90668
编号系统
MDL号
MFCD09833899
物化性质
密度
1.23g/cm3
沸点
557.9ºC at 760mmHg
闪点
291.2ºC
折射率
1.648
蒸汽压
1.76E-12mmHg at 25°C
