化合物简介
trans-4-Hydroxycrotonic acid (T-HCA), also known as γ-hydroxycrotonic acid (GHC), is an agent used in scientific research to study the GHB receptor. It is an analogue of γ-hydroxybutyric acid (GHB), as well as an active metabolite of GHB. Similarly to GHB, T-HCA has been found to be endogenous to the rat central nervous system, and as a metabolite of GHB, is almost certain to be endogenous to humans as well. T-HCA binds to the high-affinity GHB receptor with 4-fold greater affinity than GHB itself, where it acts as an agonist, but does not bind to the low-affinity GHB binding site, the GABAB receptor. Because of this, T-HCA does not produce sedation, and instead causes convulsions, which are thought to be caused by GHB receptor activation-evoked increases in extracellular glutamate concentrations, with one notable area where this occurs being the hippocampus.
基本信息
中文名称
4-羟基-2-丁烯酸
英文名称
(E)-4-Hydroxycrotonic Acid
中文别名
英文别名
4-HYDROXY-BUT-2-ENOIC ACID
CAS号
24587-49-3
分子式
C4H6O3
分子量
102.089
精确质量
102.032
PSA
57.53
LOGP
-0.3805
编号系统
MDL号
MFCD00673880
物化性质
沸点
338.7ºC at 760 mmHg
闪点
172.9ºC
蒸汽压
6.49E-06mmHg at 25°C
安全信息
海关编码
2918199090