化合物简介
Dihydroergocryptine (DHEC, trade names Almirid, Cripar) is a dopamine agonist of the ergoline chemical class that is used as an antiparkinson agent. Dihydroergocryptine has been shown to be particularly effective as monotherapy in the early stages of Parkinson's disease. Initial monotherapy with a dopamine agonist (other examples include pergolide, pramipexole, and ropinirole) is associated with reduced risk for motor complications in Parkinson patients relative to levodopa. DHEC, like other dopamine agonists, aims to mimic the endogenous neurotransmitter and exert an antiparkinsonian effect. Recent evidence also supports that dopamine receptor agonists, instead of L-DOPA may slow or prevent the progression of Parkinson's disease.
基本信息
中文名称
二氢麦角隐亭
英文名称
dihydro-α-ergocryptine
中文别名
英文别名
Dihydroergokryptine、Dihydroergocryptine、EINECS 246-993-6、Dihydroergocriptine、dihydro-alpha-ergocryptine
CAS号
25447-66-9
分子式
C32H43N5O5
分子量
577.714
精确质量
577.326
PSA
121.7
LOGP
3.1746
编号系统
UNII
202229IR8Y
物化性质
密度
1.36g/cm3
沸点
848.7ºC at 760 mmHg
闪点
467.1ºC
折射率
1.667
蒸汽压
1.26E-30mmHg at 25°C
上游原料
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