化合物简介
Torcetrapib (CP-529,414, Pfizer) was a drug being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease. Its development was halted in 2006 when phase III studies showed excessive all-cause mortality in the treatment group receiving a combination of atorvastatin (Lipitor) and torcetrapib.
基本信息
中文名称
托彻普
英文名称
torcetrapib
中文别名
(2R,4S)-4-[(3,5-双三氟甲基苄基)甲氧基甲酰氨基]-2-乙基-6-三氟甲基-3,4-二氢-2H-喹啉-1-羧酸乙酯
英文别名
Torcetrapib、ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate
CAS号
262352-17-0
分子式
C26H22D3F9N2O4
分子量
603.492
精确质量
603.186
PSA
59.08
LOGP
8.2629
编号系统
UNII
4N4457MV2U
物化性质
外观与性状
液体
密度
1.42g/cm3
沸点
504.8ºC at 760mmHg
熔点
54-58ºC
闪点
259.1ºC
折射率
1.511
蒸汽压
2.58E-10mmHg at 25°C
合成路线
上游原料
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