化合物简介
(4R)-3-[(2S,5R)-5-(4-Fluorophenyl)-2-[(R)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is an intermediate in the preparation of Ezetimibe.
基本信息
中文名称
3-[(2R,5S)-5-(4-氟苯基)-2-[(S)-[(4-氟苯基(氨基)]][4-(三甲基硅)氧]苯基]甲基]-1-氧代-5-[(三甲基硅)氧]苯基]-4-苯基-(4S)-2-恶唑烷酮
英文名称
3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone
中文别名
3-[(2R,5S)-5-(4-氟苯基)-2-[(S)-[(4-氟苯基(氨基)]][4-(三甲基硅)氧]苯基]甲基]-1、(4S)-3-{(2R,5S)-5-(4-氟苯基 )-2-[(S)-(4-氟苯基 ) 氨基 ][4-( 三甲基硅氧基 ) 苯基 ] 甲基 }-1-氧代-(5-三甲基硅氧基 ) 戊基 ]-4-苯基-2-噁唑烷酮
英文别名
INTERMEDIATE OF EZETIMIBE、2-OXAZOLIDINONE,3-[(2R,5S)-5-(4-FLUOROPHENYL)-2-[(S)-[(4-FLUOROPHENYL)AMINO][4-[(TRIMETHYLSILYL)OXY]PHENYL]METHYL]-1-OXO-5-[(TRIMETHYLSILYL)OXY]PENTYL]-4-PHENYL-,(4S)、3-[(2R,5S)-5-(4-FLUOROPHENYL)-2-[(S)-[(4-FLUOROPHENYL( AMINO)]] [4-[TRIMETHYLSILYL]-OXY]PHENYL]METHYL]-1-OXO-5-[(TRIMETHYLSILY)-OXY]PENTYL]-4-PHENYL-(4S)-2-OXAZOLIDINONE(INTERMEDIATE OF EZETIMIBE)、3-[(2R,5S)-5-(4-fluorophenyl)-2-{(S)-[4-fluorophenyl]Amino}[4-(trimethylsily)-oxy]pentyl]methyl-1-2oxo-5-(trimethylsilyl)-oxo]penyl]-4-phenyl-(4S)-2-oxazolidinone、3-(2R,5S)-5-(4-fluorophenyl)-2-(S)-(4-fluorophenyl(amino)4-trimethylsilyl-oxyphenylmethyl-1-oxo-5-(trimethylsily)-oxypentyl-4-phenyl-(4S)-2-oxazolidinone、3-[(2r,5s)-5-(4-Fluorophenyl)-2-[(S)-[(4-Fluorophenyl( Amino)]][4-[Trimethylsilyl]-Oxy]Phenyl]Methyl]-1-Oxo-5-[(Trimethylsilyl)-Oxy]Pentyl]-4-Phenyl-(4s)-2-Oxazolidinone、(S)-3-((2R,5S)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)aMino)(4-((triMethylsilyl)oxy)phenyl)Methyl)-5-((triMethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one、E3:3-[(2R,5S)-5-(4-fluorophenyl)-2-{(S)-[(4-fluorophenyl)Amino]}[4-(trimethylsilyl)-oxy]pentyl]methyl-1-2oxo-5-( trimethylsilyl)-oxo]penyl]-4-phenyl-(4S)-2-oxazolidinone
CAS号
272778-12-8
分子式
C39H46F2N2O5Si2
分子量
716.961
精确质量
716.291
PSA
77.1
LOGP
10.0519
物化性质
密度
1.177g/cm3
沸点
747.2ºC at 760 mmHg
折射率
1.565
蒸汽压
2.64E-22mmHg at 25°C
合成路线