8-羟基-3-甲基-3,4-二氢-1,7,12(2H)-苯并[a]蒽三酮

CAS号：28882-53-3

英文名：Ochromycinone

分子式

C19H14O4

熔点

160-162ºC

密度

1.387g/cm3

分子量

306.312

沸点

568.6ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

An angucycline antibiotic. A novel Stat3 selective inhibitor. It inhibits Stat3 dimerazation and DNA binding as well as Stat3-dependent luciferase reporter activity.

基本信息

中文名称

8-羟基-3-甲基-3,4-二氢-1,7,12(2H)-苯并[a]蒽三酮

英文名称

Ochromycinone

中文别名

英文别名

(3S)-8-hydroxy-3-methyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione

CAS号

28882-53-3

分子式

C19H14O4

分子量

306.312

精确质量

306.089

PSA

71.44

LOGP

2.9326

物化性质

密度

1.387g/cm3

沸点

568.6ºC at 760 mmHg

熔点

160-162ºC

闪点

311.7ºC

折射率

1.666

蒸汽压

1.57E-13mmHg at 25°C

安全信息

海关编码

2914400090

合成路线

130548-10-6

8-甲氧基-3-甲基-3,4-二氢-1,7,12(2H)-四苯e三酮

28882-53-3

8-羟基-3-甲基-3,4-二氢-1,7,12(2H)-苯并[a]蒽三酮

上游原料

(1S,3S,6S,6aR,12aR,12bS)-1,8-dihydroxy-6-methoxy-3-methyl-1,2,3,4,6,6a,12a,12b-octahydrotetraphene-7,12-dione

1577-22-6

5-己烯酸

949087-72-3

(R)-(3-vinylcyclohex-3-enyl)methyl 4-methylbenzenesulfonamide

上游原料

(+)-Emycin A 5-羟基对萘醌 (R)-(+)-3-甲基环己酮 (1S,3S,6S,6aR,12aR,12bS)-1,8-dihydroxy-6-methoxy-3-methyl-1,2,3,4,6,6a,12a,12b-octahydrotetraphene-7,12-dione 5-己烯酸 (R)-(3-vinylcyclohex-3-enyl)methyl 4-methylbenzenesulfonamide (R)-2-(prop-2-ynyl)hex-5-enyl 4-methylbenzenesulfonate (R)-8-羟基-3-甲基-1,2,3,4-四氢苯并[a]蒽-7,12-二酮 (6-bromo-5,8-dioxonaphthalen-1-yl) acetate (4S)-4-benzyl-3-((R)-2-(prop-2-ynyl)hex-5-enoyl)oxazolidin-2-one (S)-(1S,3S,6S,6aR,12aR,12bS)-8-hydroxy-6-methoxy-3-methyl-7,12-dioxo-1,2,3,4,6,6a,7,12,12a,12b-decahydrotetraphen-1-yl 2-methoxy-2-phenylacetate (R)-2-(prop-2-ynyl)hex-5-en-1-ol 8-甲氧基-3-甲基-3,4-二氢-1,7,12(2H)-四苯e三酮 (R)-5-methyl-1-vinylcyclohex-1-ene (S)-7,8,12-trimethoxy-3-methyl-3,4-dihydrotetraphen-1(2H)-one (4S)‐4‐benzyl‐3‐(hex‐5‐enoyl)‐1,3‐oxazolidin‐2‐one