化合物简介
Befetupitant (Ro67-5930) is a drug developed by Hoffmann-La Roche which acts as a potent and selective antagonist for the NK1 receptor. It was originally developed as a potential antiemetic drug, though development was ultimately discontinued after a related drug netupitant was deemed to be more suitable for clinical development. Befetupitant has however continued to be researched for other possible applications such as treatment of corneal neovascularization.
基本信息
中文名称
2-[3,5-二(三氟甲基)苯基]-N,2-二甲基-N-[4-(2-甲基苯基)-6-吗啉-4-基-吡啶-3-基]丙酰胺
英文名称
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-morpholin-4-ylpyridin-3-yl]propanamide
中文别名
英文别名
Befetupitant、UNII-RSH7NDI7MI、Ro 67-5930
CAS号
290296-68-3
分子式
C29H29F6N3O2
分子量
565.55
精确质量
565.216
PSA
45.67
LOGP
6.9368
编号系统
UNII
RSH7NDI7MI
物化性质
密度
1.283g/cm3
沸点
599.8ºC at 760mmHg
闪点
316.6ºC
折射率
1.537
蒸汽压
2.39E-14mmHg at 25°C
合成路线
上游原料
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