百科

奈妥吡坦

奈妥吡坦

CAS号：290297-26-6

英文名：netupitant

分子式

C30H32F6N4O

熔点

密度

1.255

分子量

578.592

沸点

597.4ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Netupitant is an antiemitic drug. In the United States, the combination drug netupitant/palonosetron (trade name Akynzeo) is approved by the Food and Drug Administration for prevention of acute and delayed chemotherapy-induced nausea and vomiting, including highly emetogenic chemotherapy such as with cisplatin. In Europe, it is approved by the European Medicines Agency for the same indication.

基本信息

中文名称

奈妥吡坦

英文名称

netupitant

中文别名

英文别名

Netupitant、2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide、UNII-7732P08TIR、Netupitan

CAS号

290297-26-6

分子式

C30H32F6N4O

分子量

578.592

精确质量

578.248

PSA

39.68

LOGP

6.7899

编号系统

MDL号

MFCD25976831

物化性质

密度

1.255

沸点

597.4ºC at 760 mmHg

闪点

315.1ºC

折射率

1.539

蒸汽压

3.09E-14mmHg at 25°C

合成路线

N-甲基-4-(2-甲基苯基)-6-(4-甲基-1-哌嗪基)-3-吡啶胺

N-甲基-4-(2-甲基苯基)-6-(4-甲基-1-哌嗪基)-3-吡啶胺

α,α-dimethyl-3,5-bis(trifluoromethyl)benzeneacetyl chloride

α,α-dimethyl-3,5-bis(trifluoromethyl)benzeneacetyl chloride

奈妥吡坦

上游原料

共找到26个上游原料 >

6-氯烟酸

N-甲基哌嗪

2-Propenoic acid, 2-cyano-3-(2-methylphenyl)-, methyl ester

2-Propenoic acid, 2-cyano-3-(2-methylphenyl)-, methyl ester

2-氯-5-硝基吡啶

2-氯-5-硝基吡啶

6-氯烟酰氯

2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide

2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide

上游原料

6-氯烟酸 N-甲基哌嗪 2-Propenoic acid, 2-cyano-3-(2-methylphenyl)-, methyl ester 2-氯-5-硝基吡啶 6-氯烟酰氯 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide 6-氯-4-邻甲苯基烟酸 3-Pyridinamine, 4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)- 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-propionamide N-[4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-2,2-dimethyl-propionamide 6-氯烟酰叔丁胺 N-甲基-4-(2-甲基苯基)-6-(4-甲基-1-哌嗪基)-3-吡啶胺 α,α-dimethyl-3,5-bis(trifluoromethyl)benzeneacetyl chloride 2,6-dichloro-4-(2-methylphenyl)pyridine-3-carbonitrile 邻甲苯基氯化镁 2-(4-甲基-1-哌嗪基)-5-硝基吡啶 5-氨基-2-(4-甲基-1-哌嗪基)吡啶 6-氯-4-邻甲苯基-烟酰胺 2-(3,5-双-三氟甲基-苯基)- 2-甲基-丙酸 3,5-双三氟甲基溴苯 2-[3,5-双(三氟甲基)苯基]丙-2-醇 6-(4-甲基哌嗪-1-基)-4-(2-甲基苯基)烟酰胺 [6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl]-carbamic acid methyl ester N-tert-butyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide 2-甲基苯甲醛