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水仙环素

水仙环素

CAS号：29477-83-6

英文名：Narciclasine

分子式

C14H13NO7

熔点

密度

1.85g/cm3

分子量

307.256

沸点

733.8ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Narciclasine is a toxic alkaloid found in various Amaryllidaceae species.

基本信息

中文名称

水仙环素

英文名称

Narciclasine

中文别名

英文别名

(2S,3R,4S,4aR)-2,3,4,7-tetrahydroxy-3,4,4a,5-tetrahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

CAS号

29477-83-6

分子式

C14H13NO7

分子量

307.256

精确质量

307.069

PSA

128.48

LOGP

-0.9586

物化性质

密度

1.85g/cm3

沸点

733.8ºC at 760 mmHg

闪点

397.6ºC

折射率

1.796

蒸汽压

1.31E-22mmHg at 25°C

合成路线

(2S,5aS,2aR,5bR)-2,8-dihydroxy-4,4-dimethyl-2,6,2a,5a,5b-pentahydro-10H-1,3-dioxolano(4,5-c)1,3-dioxoleno(4,5-j)phenanthridin-7-one

(2S,5aS,2aR,5bR)-2,8-dihydroxy-4,4-dimethyl-2,6,2a,5a,5b-pentahydro-10H-1,3-dioxolano(4,5-c)1,3-dioxoleno(4,5-j)phenanthridin-7-one

水仙环素

上游原料

共找到51个上游原料 >

(1S,2R,4aS,11bR)-1-((tert-butyldimethylsilyl)oxy)-2,7-dihydroxy-5-(4-methoxybenzyl)-1,4a,5,11b-tetrahydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one

(1S,2R,4aS,11bR)-1-((tert-butyldimethylsilyl)oxy)-2,7-dihydroxy-5-(4-methoxybenzyl)-1,4a,5,11b-tetrahydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one

Acetic acid (3aS,3bR,10bR,11S,12S,12aS)-6-acetoxy-11-hydroxy-4-(4-methoxy-benzyl)-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydro-1,3,7,9-tetraoxa-4-aza-dicyclopenta[a,h]phenanthren-12-yl ester

Acetic acid (3aS,3bR,10bR,11S,12S,12aS)-6-acetoxy-11-hydroxy-4-(4-methoxy-benzyl)-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydro-1,3,7,9-tetraoxa-4-aza-dicyclopenta[a,h]phenanthren-12-yl ester

(1R,2R,3S,4R,4aR,10bS)-1-acetoxy-2-((t-butyldimethylsilyl)oxy)-7-(o-carbamoyloxypiperonyl)-3,4-(isopropylidenedioxy)-8,9-(methylenedioxy)-5-(p-nitrobenzenesulfonyl)-1,1a,2,3,4,4a,6-heptahydrophenanthridine

(1R,2R,3S,4R,4aR,10bS)-1-acetoxy-2-((t-butyldimethylsilyl)oxy)-7-(o-carbamoyloxypiperonyl)-3,4-(isopropylidenedioxy)-8,9-(methylenedioxy)-5-(p-nitrobenzenesulfonyl)-1,1a,2,3,4,4a,6-heptahydrophenanthridine

4-(1-Ethoxy-ethoxy)-benzo[1,3]dioxole-5-carboxylic acid [(1R,5S,6R)-5-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[4.1.0]hept-3-en-3-yl]-amide

4-(1-Ethoxy-ethoxy)-benzo[1,3]dioxole-5-carboxylic acid [(1R,5S,6R)-5-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[4.1.0]hept-3-en-3-yl]-amide

methyl 6-[(3aS,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-4-[(phenylmethoxy)amino]-6-phenylthio-2,3,4,7,3a,7a-hexahydro-1,3-dioxainden-5-yl]-4-methoxy-2H-benzo[d]1,3-dioxolene-5-carboxylate

methyl 6-[(3aS,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-4-[(phenylmethoxy)amino]-6-phenylthio-2,3,4,7,3a,7a-hexahydro-1,3-dioxainden-5-yl]-4-methoxy-2H-benzo[d]1,3-dioxolene-5-carboxylate

7-aminocarbomethoxy-2,2-dimethyl-6-(7-methoxybenzo[d][1,3]dioxol-5-yl)-(3aR,4S,7R,7aS)-4,7-dihydro[d][1,3]dioxol-4-yl benzoate

7-aminocarbomethoxy-2,2-dimethyl-6-(7-methoxybenzo[d][1,3]dioxol-5-yl)-(3aR,4S,7R,7aS)-4,7-dihydro[d][1,3]dioxol-4-yl benzoate

上游原料

(1S,2R,4aS,11bR)-1-((tert-butyldimethylsilyl)oxy)-2,7-dihydroxy-5-(4-methoxybenzyl)-1,4a,5,11b-tetrahydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one Acetic acid (3aS,3bR,10bR,11S,12S,12aS)-6-acetoxy-11-hydroxy-4-(4-methoxy-benzyl)-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydro-1,3,7,9-tetraoxa-4-aza-dicyclopenta[a,h]phenanthren-12-yl ester (1R,2R,3S,4R,4aR,10bS)-1-acetoxy-2-((t-butyldimethylsilyl)oxy)-7-(o-carbamoyloxypiperonyl)-3,4-(isopropylidenedioxy)-8,9-(methylenedioxy)-5-(p-nitrobenzenesulfonyl)-1,1a,2,3,4,4a,6-heptahydrophenanthridine 4-(1-Ethoxy-ethoxy)-benzo[1,3]dioxole-5-carboxylic acid [(1R,5S,6R)-5-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[4.1.0]hept-3-en-3-yl]-amide methyl 6-[(3aS,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-4-[(phenylmethoxy)amino]-6-phenylthio-2,3,4,7,3a,7a-hexahydro-1,3-dioxainden-5-yl]-4-methoxy-2H-benzo[d]1,3-dioxolene-5-carboxylate 7-aminocarbomethoxy-2,2-dimethyl-6-(7-methoxybenzo[d][1,3]dioxol-5-yl)-(3aR,4S,7R,7aS)-4,7-dihydro[d][1,3]dioxol-4-yl benzoate (3aS,3bR,10bR,11S,12R,12aS)-11-((tert-butyldimethylsilyl)oxy)-4-(4-methoxybenzyl)-2,2-dimethyl-5-oxo-3a,3b,4,5,10b,11,12,12a-octahydrobis([1,3]dioxolo)[4,5-c:4',5'-j]phenanthridine-6,12-diyl diacetate methyl 2-hydroxy-7-oxabicyclo[4.1.0]hept-3-ene-4-carboxylate 3,5-dibromo-(1S,2S)-3,5-cyclohexadiene-1,2-diol conduramine 6-aminocarbomethoxy-1,2-diacetoxy-5-(7-methoxybenzo[d][1,3]dioxol-5-yl)-4-cyclohexene-1-yl benzoate 2,3-(亚甲二氧基)苯甲醛 2-hydroxy-3,4-(methylenedioxy)benzaldehyde (1S,2S,3S,4R,5R,6S)-3-((t-butyldimethylsilyl)oxy)-6-(N-(o-carbamoyloxypiperonyl)-N-(p-nitrobenzenesulfonyl)amino)-4,5-epoxy-1,2-O-isopropylidenecyclohexane-1,2-diol methyl 6-<(3aS,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-4-<(phenylmethoxy)amino>-6-phenylthio-2,3,4,7,3a,7a-hexahydro-1,3-dioxainden-5-yl>-4-<(4-methylphenyl)sulfonyloxy>-2H-benzo<d>1,3-dioxolene-5-carboxylate methyl 6-[(3aS,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-4-[(phenylmethoxy)amino]-6-phenylthio(2,3,4,7,3a,7a-hexahydro-1,3-dioxainden-5-yl)]-4-hydroxy-2H-benzo[d]1,3-dioxolene-5-carboxylate 2,4-Cyclohexadien-1-carbonsaeure-methylester Diethyl-carbamic acid 5-bromomethyl-benzo[1,3]dioxol-4-yl ester 5-bromo-4-(1-ethoxyethoxy)-2H-benzo[d]1,3-dioxolane (3aR,7aS)-2,2-dimethyl-3a,7a-dihydrobenzo[d][1,3]dioxole (2S,5aS,2aR,5bR)-2,8-dihydroxy-4,4-dimethyl-2,6,2a,5a,5b-pentahydro-10H-1,3-dioxolano(4,5-c)1,3-dioxoleno(4,5-j)phenanthridin-7-one 2,3,4-trihydroxy-7-methoxy-(2S,3R,4S,4aR)-2,3,4,6-tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6-one (2S,3S,4R,4aR)-5-(t-butoxycarbonyl)-2-((t-butyldimethylsilyl)oxy)-7-(o-carbamoyloxypiperonyl)-3,4-(isopropylidenedioxy)-8,9-(methylenedioxy)-2,3,4,4a-tetrahydrophenanthridone 4-羟基-1,3-苯并二氧代 tert-Butyl-((1R,2S,6R)-4-isocyanato-7-oxa-bicyclo[4.1.0]hept-3-en-2-yloxy)-dimethyl-silane 7-aminocarbomethoxy-2,2-dimethyl-6-(7-methoxybenzo[d][1,3]dioxol-5-yl)-(3aS,7R,7aS)-4,7-dihydro[d][1,3]dioxol-4-one (6aS,7aR,8aR,9S,9aR)-9-((tert-butyldimethylsilyl)oxy)-4-hydroxy-6-(4-methoxybenzyl)-6a,7,7a,8a,9,9a-hexahydro-[1,3]dioxolo[4,5-j]oxireno[2,3-b]phenanthridin-5(6H)-one (2S,5aS,2aR,5bR)-2-hydroxy-8-methoxy-4,4-dimethyl-6-(phenylmethoxy)-1-phenylthio-2,6,2a,5a,5b-pentahydro-10H-1,3-dioxolano[4,5-c]1,3-dioxoleno[4,5-j]phenanthridin-7-one N-((1R,5S,6R)-5-((tert-butyldimethylsilyl)oxy)-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-4-hydroxy-N-(4-methoxybenzyl)benzo[d][1,3]dioxole-5-carboxamide (3aS,3bR,12S,12aR)-4-(4-methoxybenzyl)-2,2-dimethyl-5-oxo-3a,3b,4,5,12,12a-hexahydrobis([1,3]dioxolo)[4,5-c:4',5'-j]phenanthridine-6,12-diyl diacetate (3aS,3bR,12S,12aR)-6,12-dihydroxy-4-(4-methoxybenzyl)-2,2-dimethyl-3b,4,12,12a-tetrahydrobis([1,3]dioxolo)[4,5-c:4',5'-j]phenanthridin-5(3aH)-one 6-aminocarbomethoxy-1,2-dihydroxy-5-(7-methoxybenzo[d][1,3]dioxol-5-yl)-4-cyclohexene-1-yl benzoate 2,3-二羟基苯甲醛 7-aminocarbomethoxy-2,2-dimethyl-6-(7-methoxybenzo[d][1,3]dioxol-5-yl)-(3aR,4R,7R,7aS)-4,7-dihydro[d][1,3]dioxol-4-ol Acetic acid (1S,2R,4aS,11bR)-7-acetoxy-1-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyl)-6-oxo-1,2,4a,5,6,11b-hexahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester 1,8-dibromo-11-carbomethoxy-4,4-dimethyl-(1R,2S,6S,7S)-3,5,10,11-trioxaazatricyclo[5.2.2.02,6]-8-undecene methyl 5-(butyryloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate (+)-methyl (1β,2α,6β)-2-hydroxy-7-oxabicyclo[4,1,0]hept-3-ene-4-carboxylate 4-(1-Ethoxy-ethoxy)-benzo[1,3]dioxole-5-carboxylic acid [(1R,5S,6R)-5-(tert-butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[4.1.0]hept-3-en-3-yl]-(4-methoxy-benzyl)-amide 3-环己烯-1-羧酸甲酯 3,4-diacetoxy-7-methoxy-(2S,3R,4S,4aR)-2,3,4,6-tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6-one-2-yl benzoate bromo-5 hydroxy-4 benzodioxole-1,3 (+)-5-(tert-butyl-dimethylsilanyloxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylic acid methyl ester 5-formylbenzo[d][1,3]dioxol-4-yl diethylcarbamate tert-butyl (3aS,3bR,10bS,11R,12S,12aS)-11-acetoxy-12-((tert-butyldimethylsilyl)oxy)-6-((diethylcarbamoyl)oxy)-2,2-dimethyl-5-oxo-3a,5,10b,11,12,12a-hexahydrobis([1,3]dioxolo)[4,5-c:4',5'-j]phenanthridine-4(3bH)-carboxylate 1,3-二溴苯