化合物简介
5α-Dihydrocorticosterone ((5α,11β)-11,21-dihydroxypregnane-3,20-dione; abbreviated as 5α-DHC, 5α-DHB) is a naturally-occurring, endogenous glucocorticoid steroid hormone and neurosteroid. It is biosynthesized from corticosterone by the enzyme 5α-reductase. DHC has central depressant effects and impairs long-term potentiation in animals.
基本信息
中文名称
5-Alpha-二氢皮质酮
英文名称
(5S,8S,9S,10S,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
中文别名
英文别名
5|A-Pregnane-11|A,21-diol-3,20-dione、5|A-Dihydrocorticosterone、5beta-Dihydrocorticosterone、5-Dihydrocorticosterone、5alpha-Dihydrocorticosterone
CAS号
298-25-9
分子式
C21H32O4
分子量
348.476
精确质量
348.23
PSA
74.6
LOGP
2.7466
物化性质
密度
1.175 g/cm3
沸点
508.5ºC at 760 mmHg
闪点
275.4ºC
折射率
1.548
蒸汽压
1.82E-12mmHg at 25°C