化合物简介
Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker, it is also known to promote cerebral blood flow, and so is used to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis. However, it is more commonly prescribed for nausea and vomiting due to motion sickness or other sources such as chemotherapy, vertigo, or Ménière's disease. Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955. The nonproprietary name is derived from the cinnamyl substituent on one of the nitrogen atoms, combined with the generic ending \"-rizine\" for \"antihistaminics/cerebral (or peripheral) vasodilators\". It is not available in the United States or Canada. It is manufactured and marketed in Bangladesh under the trade name Suzaraon by Rephco Pharmaceuticals Limited. It has also been cited as one of the most used drugs for seasickness within the British Royal Navy.
基本信息
中文名称
桂利嗪
英文名称
cinnarizine
中文别名
1-反式-肉桂基-4-二苯基甲基哌嗪、1-二苯甲基-4-(3-苯基-2-丙烯基)哌嗪、肉桂嗪
英文别名
1-trans-Cinnamyl-4-diphenylmethylpiperazine、Stugeron、Cinnarizine
CAS号
298-57-7
分子式
C26H28N2
分子量
368.514
精确质量
368.225
PSA
6.48
LOGP
4.9828
编号系统
UNII
3DI2E1X18L
物化性质
外观与性状
白色粉末
密度
1.093g/cm3
沸点
509.2ºC at 760mmHg
熔点
117-120ºC
闪点
229.8ºC
折射率
1.649
储存条件
Refrigerator
蒸汽压
2.35E-10mmHg at 25°C
安全信息
RTECS号
TL3430000
安全说明
S22; S24/25; S36; S26
WGK Germany
2
危险类别码
R20/22
海关编码
2933599090
危险品标志
Xn
生产方法及用途
生产方法
由无水哌嗪与溴代二苯甲烷制取二苯甲基哌嗪,再与苯丙烯氯缩合而得。二苯甲烷在光照下加热,滴加溴素,在130℃保温1h,即得溴代二苯甲烷,C13H11Br,[776-74-9],熔点45℃。将溴代二苯甲烷滴加到哌嗪甲苯液中,于80-90℃搅拌3h,冷却后用水洗涤反应液,再用10%稀盐酸萃取,将酸层碱化析出沉淀,过滤烘干,得二苯甲基哌嗪。将其溶解在95%乙醇中,加入碳酸钠,在65℃左右滴加苯丙烯氯,滴完后,加热回流4h,趁热过滤,滤液放置过液,析出结晶,过滤,得脑益嗪粗品,经精制,得熔点117-119℃的成品。以二苯甲烷计,总收率48.2%。
用途
长效多功能的血管收缩拮抗剂,能扩张血管,改善血循环,预防血管脆化,可用于治疗脑血管疾病,对颈性眩晕等引起的头痛,头晕失眠、记忆力减退,偏瘫,肢体麻木无力,言语不清等症也有疗效。
海关数据
共找到1个国家海关数据 >国家/地区名称 | 海关编码 | 更新时间 | 操作 |
---|---|---|---|
中国 | 2933599090 | 2019-03 | 查看 |