化合物简介
Methoxsalen — also called xanthotoxin, marketed under the trade names Oxsoralen, Deltasoralen, Meladinine — is a drug used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to UVA light from lamps or sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. The dosage comes in 10mg tablets, which are taken in the amount of 30mg 75minutes before a PUVA (psoralen + UVA) light treatment. Chemically, methoxsalen belongs to a class of organic natural molecules known as furanocoumarins. They consist of coumarin annulated with furan. It can also be injected and used topically.
基本信息
中文名称
8-甲氧基补骨脂素
英文名称
methoxsalen
中文别名
花椒毒素、甲氧沙林、甲氧基补骨脂素
英文别名
9-methoxypsoralen、Puvalen、Xanthotoxin、8-methoxypsoralene、8-MP、8-MOP,9-Methoxyfuro[3,2-g][1]benzopyran-7-one,Ammoidin、Methoxsalen、Puvamet、Dermox、xanthotoxin、Meloxine、7H-Furo[3,2-g][1]benzopyran-7-one, 9-methoxy-、9-Methoxy-7H-furo[3,2-g]chromen-7-one、Uvadex、8-MOP,8-Methoxypsoralen,9-Methoxyfuro[3,2-g][1]benzopyran-7-one、8-MOP、Vitpso、Metoxin、8-Methoxypsoralen、Ammodin
CAS号
298-81-7
分子式
C12H8O4
分子量
216.19
精确质量
216.042
PSA
52.58
LOGP
2.5478
编号系统
MDL号
MFCD00005009
物化性质
外观与性状
无气味的白色至奶油色的结晶固体,苦味道
密度
1.368g/cm3
沸点
414.8ºC at 760mmHg
熔点
148-150°C(lit.)
闪点
204.7ºC
折射率
1.635
水溶解性
PRACTICALLY INSOLUBLE
稳定性
Stable under normal temperatures and pressures. May decompose when exposed to light.
储存条件
Corrosives area. Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.
蒸汽压
4.33E-07mmHg at 25°C
安全信息
RTECS号
LV1400000
安全说明
S36/37-S53-S45-S36/37/39-S26
WGK Germany
3
危险类别码
R22; R34; R45; R46
海关编码
2932999099
危险品运输编码
3216
危险类别
6.1
包装等级
I; II; III
危险品标志
T
生产方法及用途
用途
用于治疗牛皮癣、白癫风等疾病
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