化合物简介
Proadifen (SKF-525A) is a non-selective inhibitor of cytochrome P450 enzymes, preventing some types of drug metabolism. It is also an inhibitor of neuronal nitric oxide synthase (NOS), CYP-dependent (cytochrome P450-dependent) arachidonate metabolism, transmembrane calcium influx, and platelet thromboxane synthesis. Further documented effects include the blockade of ATP-sensitive inward rectifier potassium channel 8 (KIR6.1), and stimulation of endothelial cell prostacyclin production.
基本信息
中文名称
普罗地芬
英文名称
2-(Diethylamino)ethyl 2,2-diphenylpentanoate
中文别名
英文别名
HL 8727、Proadifeno [INN-Spanish]、Proadifen [INN]、BCTB、Ethyl aprofen、Proadifene [INN-French]、Proadifenum [INN-Latin]、proadifen、ACETIC ACID,PROPYLDIPHENYL-,2-(DIETHYLAMINO)ETHYL ESTER
CAS号
302-33-0
分子式
C23H31NO2
分子量
353.498
精确质量
353.235
PSA
29.54
LOGP
4.6578
编号系统
UNII
A510CA4CBT
物化性质
密度
1.023g/cm3
沸点
460.8ºC at 760mmHg
闪点
132.3ºC
折射率
1.531
