百科

辅酶Q10

辅酶Q10

CAS号：303-98-0

英文名：coenzyme Q10

分子式

C59H90O4

熔点

49-51°C

密度

0.97 g/cm3

分子量

863.343

沸点

869ºC at 760mmHg

溶解度

信号词

危险品标志

若想填写更详细的询价信息，请点击进入询价页面

点我

化合物简介

Antibacterial and antioxidant for preventing and treating cancer.

基本信息

中文名称

辅酶Q10

英文名称

coenzyme Q10

中文别名

泛醌、泛癸利酮、万有醌、辅酶R10、2-(3,7,11,15,19,23,27,31,35,39-十甲基-2,6,10,14,18,22,26,30,34,38-四十碳十烯基)-5,6-二甲氧基-3-甲基-p-苯醌、辅酶 Q10、万有醌-10、2,3-二甲氧基-5-甲基-6[3-甲基丁烯基-2]苯醌、泛醌-50

英文别名

Ubidecarenone、Coenzyme Q10、Coenz10、Ubiquinone 10、Q-10 Ubiquinone 50 Ubiquinone-10、Ubiquinone 50、Liquid-Q、COQ10、ubiquinone Q10、eiquinon、Coenzyme q10、Carenone、Ubiquinone-10、neuqinon、Q-10、Q-Gel、Kudesan、Ensorb、Coenzyme Q10,Q-10,Ubiquinone 50

CAS号

303-98-0

分子式

C59H90O4

分子量

863.343

精确质量

862.684

PSA

52.6

LOGP

17.8539

编号系统

UNII

EJ27X76M46

物化性质

外观与性状

黄色-橙色结晶粉末

密度

0.97 g/cm3

沸点

869ºC at 760mmHg

熔点

49-51°C

闪点

324.5ºC

折射率

1.525

稳定性

Stable, but may be light or heat sensitive. Store in the dark at -20ºC. Incompatible with strong oxidizing agents.

储存条件

-20ºC

安全信息

RTECS号

DK3900000

安全说明

S22; S24/25; S26

WGK Germany

3

危险类别码

R36/37/38

海关编码

2932999099

危险品标志

Xi

生产方法及用途

生产方法

1.辅酶Q10可以由合成法和微生物发酵法生产。也可以从猪心肌中提取。
2.猪心肌渣皂化速冷皂化物萃取↓汽油
3.水洗减压浓缩过滤层析
4.减压浓缩结晶辅酶Q10结晶
5.提取细胞色素C后的心渣,以水漂洗去除(N
H4)2SO4和脂肪,甩干,加入焦性没食子酸拌匀。另于回流罐中加入约2倍量乙醇,再加固体烧碱,搅拌溶解,配制成碱浓度约为10%(质量浓度)的醇碱溶液,然后投入拌有焦性没食子酸的心渣,迅速加热至沸,回流25～30min皂化。再迅速冷却至室温,在冷却的皂化物中,加入适量120号汽油,萃取三次,使萃取完全,合并萃取液,以水反复洗涤至近中性。将水洗后的萃取液减压浓缩至原体积的1/10左右,低温过滤除去析出的杂质(主要是胆固醇)。将澄清滤液加入硅胶层析柱。先用120号汽油洗涤去杂质,再用乙醚汽油混合液(1∶10,体积分数)洗脱,收集黄色带部分的洗脱液。在黄色油状洗脱液中,加入适量无水乙醇,温热使溶解完全。趁热过滤,滤液置冰箱中使结晶完全。滤得结晶,在无水乙醇中重结晶或经硅胶柱再层析,可得纯度更高的辅酶Q10。
6.除上述皂化法外,尚有溶剂直接提取法和溶剂提取皂化法。溶剂提取法的收率不如皂化法,但省除了应用焦没食子酸。较大量的焦没食子酸在皂化过程中可能产生乙氧基衍生物,皂化过程中也可充入氮气。正己烷、正庚烷、异辛烷、环己烷、乙醚以及乙醇和乙醚混合溶剂都可用来提取辅酶Q10。层析纯化的吸附剂可用硅胶和氧化铝等。
7. 烟草:FC,BU,1。

用途

1.辅酶Q10是线粒体电子传递链的重要成员之
一,也在氧化磷酸化中起重要作用。可用于治疗心脏病,如心肌梗死、狭心症等。作为机体非特异性免疫增强剂,广泛用于治疗细菌或病毒性感染,如病毒性肝炎、亚急性肝坏死、暴发性肝炎所致的脑水肿、迁延性肝炎和慢性肝炎等。也可用于肿瘤病人的综合治疗,以改善其免疫功能。
2.细胞呼吸和细胞代谢的激活剂,也是机体的非特异性免疫增强剂。用于急、慢性病毒性肝炎,亚急性肝坏死等症,也用于癌症的辅助治疗、细菌和病毒感染等。

合成路线

三甲基铝

2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

(all-E)-2,6,10,14,18,22,26,30,34-nonamethyl-2,6,10,14,18,22,26,30,34-nonacontanonaen-38-yne

(all-E)-2,6,10,14,18,22,26,30,34-nonamethyl-2,6,10,14,18,22,26,30,34-nonacontanonaen-38-yne

辅酶Q10

海关数据

共找到1个国家海关数据 >

国家/地区名称	海关编码	更新时间	操作
中国	2932999099	2019-03	查看

上游原料

共找到103个上游原料 >

1-(benzenesulfonyl)-2-methyl-4-chloro-2-butene

1-(benzenesulfonyl)-2-methyl-4-chloro-2-butene

茄尼醇

(all-E)-2,6,10,14,18,22,26,30,34-nonamethyl-2,6,10,14,18,22,26,30,34-nonacontanonaen-38-yne

(all-E)-2,6,10,14,18,22,26,30,34-nonamethyl-2,6,10,14,18,22,26,30,34-nonacontanonaen-38-yne

茄呢醇溴化物

茄呢醇溴化物

(E)-1,4-diiodo-2-methylbut-1-ene

(E)-1,4-diiodo-2-methylbut-1-ene

2-hydroxy-3,4,5-trimethoxy-6-((2E)-decaprenyl)-toluene

2-hydroxy-3,4,5-trimethoxy-6-((2E)-decaprenyl)-toluene

上游原料

1-(benzenesulfonyl)-2-methyl-4-chloro-2-butene 茄尼醇 (all-E)-2,6,10,14,18,22,26,30,34-nonamethyl-2,6,10,14,18,22,26,30,34-nonacontanonaen-38-yne 茄呢醇溴化物 (E)-1,4-diiodo-2-methylbut-1-ene 2-hydroxy-3,4,5-trimethoxy-6-((2E)-decaprenyl)-toluene ((5E,9E,13E,17E,21E,25E,29E,33E)-2,6,10,14,18,22,26,30,34,38-decamethylnonatriaconta-1,5,9,13,17,21,25,29,33,37-decaen-1-yl)dimethylaluminum (E)-6-[4-(benzenesulfonyl)-3-methylbut-2-enyl]-2,3-dimethoxy-5-methylbenzene-1,4-diol 1,4-dibenzyloxy-2,3-dimethoxy-5-methyl-6-(34'-hydroxy-3',7',11',15',19',23',27',31',35'-nonamethylhexatriaconta-2'E,6'E,10'E,14'E,18'E,22'E,26'E,30'E,35'-nonaenyl)benzene 1,4-dibenzyloxy-2,3-dimethoxy-5-methyl-6-(34',35'-epoxy-3',7',11',15',19',23',27',31',35'-nonamethylhexatriaconta-2'E,6'E,10'E,14'E,18'E,22'E,26'E,30'E-octaenyl)benzene 三甲基铝 1-[(2E)-4-bromobut-2-en-1-yl]-3,4-dimethoxy-2,5-bis(methoxymethoxy)-6-methylbenzene (5E,9E)-12-iodo-6,10-dimethyl-1-trimethylsilyl-5,9-dodecadien-1-yne solanesyl p-tolyl sulphone 2-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl)-5,6-dimethoxy-3-methylbenzene-1,4-diol 1,4-bis(benzyloxy)-2-[(2E)-4-bromo-3-methylbut-2-enyl]-5,6-dimethoxy-3-methylbenzene 4-(benzenesulfonyl)-3,7,11,15,19,23,27,31,35,39-decamethyl-1-[3,4-dimethoxy-2,5-bis(methoxymethoxy)-6-methylphenyl]tetraconta-2,6,10,14,18,22,26,30,34,38-decaene 3,4,5-三甲氧基甲苯 (2E)-4-(3,4-dimethoxy-2,5-bis(methoxymethoxy)-6-methylphenyl)-2-methylbut-2-en-1-ol (E)-1-(benzenesulfonyl)-4-[3,4-dimethoxy-2,5-bis(methoxymethoxy)-6-methylphenyl]-2-methylbut-2-ene (E)-8-iodo-6-methyl-1-trimethylsilyl-5-octen-1-yne (2'E,6'E,10'E,14'E,18'E,22'E,26'E,30'E,34'E,38'E)-1-(3',7',11',15',19',23',27',31',35',39'-decamethyltetraconta-2',6',10',14',18',22',26',30',34',38'-decaenyl)-6-methyl-2,3,4,5-tetramethoxybenzene 2,3,4-三甲氧基-6-甲基苯酚 1-{(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-5-[(4-methylphenyl)sulfonyl]tetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl}-3,4-dimethoxy-2,5-bis(methoxymethoxy)-6-methylbenzene (3E)-4-iodo-3-methyl-3-Buten-1-ol (all-E)-1-iodo-2,6,10,14,18,22-hexamethyl-1,5,9,3,17,21-tricosahexane (all-E)-6,10,14,18,22,26,30,34,38-nonamethyl-1-trimethylsilyl-5,9,13,17,21,25,29,33,37-nonacontanonaen-1-yne 2,4-dibromo-3-methoxy-6-methylphenol (2'E,6'E,10'E,14'E,18'E,22'E,26'E,30'E,34'E,38'E)-1-(3,7',11',15',19',23',27',31',35',39'-decamethyl-4'-phenylsulfonyltetraconta-2',6',10',14',18',22',26',30',34',38'-decaenyl)-6-methyl-2,3,4,5-tetramethoxybenzene 2-(chloromethyl)-5,6-dimethoxy-3-methylphenyl4-methylbenzenesulfonate toluene-4-sulfonic acid 2-(3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl)-5,6-dimethoxy-3-methylphenyl ester 癸异戊烯醇 (E,E,E,E)-6,10,14,18,22-pentamethyltricosa-5,9,13,17,21-pentaen-1-yne 1,4-bis(benzyloxy)-2-{(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-5-[(4-methylphenyl)sulfonyl]tetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl}-5,6-dimethoxy-3-methylbenzene (5E,9E,13E)-16-iodo-6,10,14-trimethyl-1-trimethylsilyl-5,9,13-hexadecatrien-1-yne (2E)-4-[2,5-bis(benzyloxy)-3,4-dimethoxy-6-methylphenyl]-2-methylbut-2-en-1-ol 2,3-二甲氧基-5-甲基-1,4-苯醌 (E)-4-(3,4-dimethoxy-2,5-bis(methoxymethoxy)-6-methylphenyl)-2-methylbut-2-en-1-yl methanesulfonate 2-bromo-3-methoxy-6-methyl-para-benzoquinone 2,3-dimethoxy-5-methyl-1,4-bismethoxymethyloxy-6-bromobenzene 1-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl)-2,3,4-trimethoxy-5-((2-methoxyethoxy)methoxy)-6-methylbenzene 异戊二烯 (5-methoxy-2-methylcyclohexa-1,5-dien-1-yl)oxy-trimethylsilane (E,E,E,E)-6,10,14,18,22-pentamethyl-1-trimethylsilyltricosa-5,9,13,17,21-pentaen-1-yne 5-methoxy-2-methylphenol Decaprenyl bromide 2-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-tetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl)-5,6-dimethoxy-3-methyl-benzene-1,4-diol