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2,4,6,8-四氯嘧啶并[5,4-d]嘧啶

2,4,6,8-四氯嘧啶并[5,4-d]嘧啶

CAS号：32980-71-5

英文名：2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE

分子式

C6Cl4N4

熔点

密度

1.871g/cm3

分子量

269.903

沸点

335.1ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Potential tyrosine kinase signal transduction inhibitor.\n\nA pyrimido[5,4-d]pyrimidine derivative used as an intermediate in the preparation of nucleoside transporter 1 inhibitors and potential modulators of the activity of antimetabolite antitumor agents.

基本信息

中文名称

2,4,6,8-四氯嘧啶并[5,4-d]嘧啶

英文名称

2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE

中文别名

四氯嘧啶并[5,4-d]嘧啶、2,4,6,8-四氯嘧啶并[5,4-D]嘧啶、四氯嘧啶并[5,4-D]嘧啶

英文别名

Tetrachloropyrimido<pyrimidin、2,4,6,8-tetrachloropyrimido<-pyrimidine、Perchloropyrimido[5,4-d]pyrimidine、2,3-DIHYDRO-5-METHYL-3-OXO-2-PHENYL-1H-PYRAZOLE-4-CARBOXALDEHYDE、2,4,6,8-tetra-chloropyrimido<5,4-d>pyrimidine

CAS号

32980-71-5

分子式

C6Cl4N4

分子量

269.903

精确质量

267.888

PSA

51.56

LOGP

3.0334

编号系统

MDL号

MFCD02093495

物化性质

密度

1.871g/cm3

沸点

335.1ºC at 760 mmHg

闪点

186.8ºC

折射率

1.704

安全信息

安全说明

S26; S36/37/39

危险类别码

R36/37/38

生产方法及用途

生产方法

1、可用氨基乳清酸与尿素在碱性病条件下环合并酸化，得到2,4,6,8-四羟基嘧啶并嘧啶，后者以氧氯化磷、三氯化磷和氯气氯化制得该品。

用途

1、哌醇啶（潘生丁）的中间体。

合成路线

共找到12条合成路线 >

5-氨基乳清酸

5-氨基乳清酸

2,4,6,8-四氯嘧啶并[5,4-d]嘧啶

2,4,6,8-四氯嘧啶并[5,4-d]嘧啶

上游原料

共找到1个上游原料 >

5-氨基乳清酸

5-氨基乳清酸

下游产品

共找到11个下游商品 >

2-[[2-[bis(2-hydroxyethyl)amino]-4,8-dimorpholin-4-ylpyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

2-[[2-[bis(2-hydroxyethyl)amino]-4,8-dimorpholin-4-ylpyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

潘生丁

2,6-dichloropyrimido[5,4-d]pyrimidine-4,8-diamine

2,6-dichloropyrimido[5,4-d]pyrimidine-4,8-diamine

2,6-BIS(2-HYDROXYETHYLAMINO)-4,8-DIPIPERIDINOPYRIMIDO(5,4-D)PYRIMIDINEDIPYRIDAMOLE

2,6-BIS(2-HYDROXYETHYLAMINO)-4,8-DIPIPERIDINOPYRIMIDO(5,4-D)PYRIMIDINEDIPYRIDAMOLE

2,6-二氯-4,8-二哌啶子基嘧啶并[5,4-D]嘧啶

2,6-二氯-4,8-二哌啶子基嘧啶并[5,4-D]嘧啶

2-[[2,6-dichloro-4-(2-hydroxyethylamino)pyrimido[5,4-d]pyrimidin-8-yl]amino]ethanol

2-[[2,6-dichloro-4-(2-hydroxyethylamino)pyrimido[5,4-d]pyrimidin-8-yl]amino]ethanol

上游原料

5-氨基乳清酸

下游产品

2-[[2-[bis(2-hydroxyethyl)amino]-4,8-dimorpholin-4-ylpyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol 潘生丁 2,6-dichloropyrimido[5,4-d]pyrimidine-4,8-diamine 2,6-BIS(2-HYDROXYETHYLAMINO)-4,8-DIPIPERIDINOPYRIMIDO(5,4-D)PYRIMIDINEDIPYRIDAMOLE 2,6-二氯-4,8-二哌啶子基嘧啶并[5,4-D]嘧啶 2-[[2,6-dichloro-4-(2-hydroxyethylamino)pyrimido[5,4-d]pyrimidin-8-yl]amino]ethanol 2,6-dichloro-4-N,8-N-diphenylpyrimido[5,4-d]pyrimidine-4,8-diamine 2,4,6,8-tetra(piperidin-1-yl)pyrimido[5,4-d]pyrimidine 2-[[8-[bis(2-hydroxyethyl)amino]-2,6-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-4-yl]-(2-hydroxyethyl)amino]ethanol 4-(2,6-dichloro-4-morpholin-4-ylpyrimido[5,4-d]pyrimidin-8-yl)morpholine 2-[[4-[bis(2-hydroxyethyl)amino]-2,6-dichloropyrimido[5,4-d]pyrimidin-8-yl]-(2-hydroxyethyl)amino]ethanol