化合物简介
Alinidine (ST567) is a negative chronotrope that was developed in the 1970s and 1980s. It causes bradycardia by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold. The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on calcium channels and potassium channels. It also causes elongation of re-polarisation after an action potential.
基本信息
中文名称
烯丙尼定
英文名称
N-(2,6-dichlorophenyl)-N-prop-2-enyl-4,5-dihydro-1H-imidazol-2-amine
中文别名
烯苯胺咪
英文别名
Alinidina [INN-Spanish]、ST-567、Alinidin、2-[N-(2,6-dichloro-phenyl)-N-allyl-amino]-2-imidazoline、2-IMIDAZOLINE,2-(N-ALLYL-2,6-DICHLOROANILINO)、Alinidinum [INN-Latin]、2-(N-Allyl-N-(2,6-dichlorophenyl)amino)-2-imidazoline、Alinidine、allyl-(2,6-dichloro-phenyl)-(4,5-dihydro-1H-imidazol-2-yl)-amine
CAS号
33178-86-8
分子式
C12H13Cl2N3
分子量
270.158
精确质量
269.049
PSA
27.63
LOGP
2.7094
编号系统
UNII
E7IDJ8DS1D
物化性质
密度
1.3g/cm3
沸点
360.2ºC at 760mmHg
闪点
171.7ºC
折射率
1.611
