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美坦新

美坦新

CAS号：35846-53-8

英文名：Maytansine

分子式

C34H46ClN3O10

熔点

171-172 °C

密度

1.32g/cm3

分子量

692.196

沸点

895.1ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Maitansine (INN), or maytansine (USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.

基本信息

中文名称

美坦新

英文名称

Maytansine

中文别名

美登素、美坦生、美登新

英文别名

maitansine、(3E,5E,7R,84S)-12c-(N-acetyl-N-methyl-L-alanyloxy)-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r\'H,86c\'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione

CAS号

35846-53-8

分子式

C34H46ClN3O10

分子量

692.196

精确质量

691.287

PSA

156.47

LOGP

3.9282

编号系统

UNII

14083FR882

物化性质

密度

1.32g/cm3

沸点

895.1ºC at 760mmHg

熔点

171-172 °C

闪点

495.1ºC

折射率

1.59

可溶性

溶于氯仿、二氯甲烷、甲醇和丙酮，不溶于乙醚和正己烷

合成路线

maytansine 9-O-methyl ether

maytansine 9-O-methyl ether

美坦新

上游原料

共找到7个上游原料 >

maytansine 9-O-methyl ether

maytansine 9-O-methyl ether

(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-5,12-dimethoxy-2,6,8,16-tetramethyl-3-oxospiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-9-yl carbamate

(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-5,12-dimethoxy-2,6,8,16-tetramethyl-3-oxospiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-9-yl carbamate

(2Z,4E)-2-formyl-5-methoxypenta-2,4-dienenitrile

(2Z,4E)-2-formyl-5-methoxypenta-2,4-dienenitrile

(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-9-hydroxy-5,12-dimethoxy-2,6,8,16-tetramethylspiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-3-one

(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-9-hydroxy-5,12-dimethoxy-2,6,8,16-tetramethylspiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-3-one

(1<sup>4</sup>S,1<sup>6</sup>S,2R,3E,5E,12S,13E,15S)-8<sup>4</sup>-chloro-12-hydroxy-1<sup>4</sup>,8<sup>5</sup>,2-trimethoxy-6,9,13,15-tetramethyl-9-aza-1(4,6)-oxazinana-8(1,3)-benzenacyclopentadecaphane-3,5,13-triene-1<sup>2</sup>,10-dione

(1<sup>4</sup>S,1<sup>6</sup>S,2R,3E,5E,12S,13E,15S)-8<sup>4</sup>-chloro-12-hydroxy-1<sup>4</sup>,8<sup>5</sup>,2-trimethoxy-6,9,13,15-tetramethyl-9-aza-1(4,6)-oxazinana-8(1,3)-benzenacyclopentadecaphane-3,5,13-triene-1<sup>2</sup>,10-dione

3-O-(tert-butyldimethylsilyl)-4,5-deoxymaytansinol

3-O-(tert-butyldimethylsilyl)-4,5-deoxymaytansinol

上游原料

maytansine 9-O-methyl ether (5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-5,12-dimethoxy-2,6,8,16-tetramethyl-3-oxospiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-9-yl carbamate (2Z,4E)-2-formyl-5-methoxypenta-2,4-dienenitrile (5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-9-hydroxy-5,12-dimethoxy-2,6,8,16-tetramethylspiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-3-one (1<sup>4</sup>S,1<sup>6</sup>S,2R,3E,5E,12S,13E,15S)-8<sup>4</sup>-chloro-12-hydroxy-1<sup>4</sup>,8<sup>5</sup>,2-trimethoxy-6,9,13,15-tetramethyl-9-aza-1(4,6)-oxazinana-8(1,3)-benzenacyclopentadecaphane-3,5,13-triene-1<sup>2</sup>,10-dione 3-O-(tert-butyldimethylsilyl)-4,5-deoxymaytansinol (-)-maytansinol