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曲西立滨

曲西立滨

CAS号：35943-35-2

英文名：triciribine

分子式

C13H16N6O4

熔点

密度

2.02g/cm3

分子量

320.304

沸点

718.5ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.

基本信息

中文名称

曲西立滨

英文名称

triciribine

中文别名

曲西瑞宾、1,5-二氢-5-甲基-1-BETA-D-呋喃核糖基-1,4,5,6,8-五氮杂苊-3-胺

英文别名

API-2 Akt/PKB Signaling Inhibitor-2 Inhibitor V、1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine、Triciribine

CAS号

35943-35-2

分子式

C13H16N6O4

分子量

320.304

精确质量

320.123

PSA

144.47

LOGP

-0.9071

编号系统

MDL号

MFCD28142766

物化性质

密度

2.02g/cm3

沸点

718.5ºC at 760mmHg

闪点

388.3ºC

折射率

1.928

合成路线

4-(1-methylhydrazino)-5-cyano-7-[(2,3,5-tri-O-benzoyl)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

4-(1-methylhydrazino)-5-cyano-7-[(2,3,5-tri-O-benzoyl)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

曲西立滨

上游原料

共找到8个上游原料 >

4-氨基-6-溴-7H-吡咯并[2,3-d]嘧啶-5-甲腈

4-氨基-6-溴-7H-吡咯并[2,3-d]嘧啶-5-甲腈

4-(1-methylhydrazino)-5-cyano-7-[(2,3,5-tri-O-benzoyl)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

4-(1-methylhydrazino)-5-cyano-7-[(2,3,5-tri-O-benzoyl)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

6-bromo-5-cyano-4-(1-methylhydrazino)-7-[2,3,5-tri-O-benzoyl-β-D-ribofuranosyl]pyrrolo[2,3-d]pyrimidine

6-bromo-5-cyano-4-(1-methylhydrazino)-7-[2,3,5-tri-O-benzoyl-β-D-ribofuranosyl]pyrrolo[2,3-d]pyrimidine

6-bromo-4-chloro-5-cyanopyrrolo[2,3-d]pyrimidin-4-one

6-bromo-4-chloro-5-cyanopyrrolo[2,3-d]pyrimidin-4-one

4-(N-methyl-hydrazino)-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-(N-methyl-hydrazino)-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

6-Bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

6-Bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

上游原料

4-氨基-6-溴-7H-吡咯并[2,3-d]嘧啶-5-甲腈 4-(1-methylhydrazino)-5-cyano-7-[(2,3,5-tri-O-benzoyl)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine 6-bromo-5-cyano-4-(1-methylhydrazino)-7-[2,3,5-tri-O-benzoyl-β-D-ribofuranosyl]pyrrolo[2,3-d]pyrimidine 6-bromo-4-chloro-5-cyanopyrrolo[2,3-d]pyrimidin-4-one 4-(N-methyl-hydrazino)-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 6-Bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile 1-乙酰基-2,3,5-三苯甲酰氧基-1-beta-D-呋喃核糖 6-bromo-4-chloro-5-cyano-7-[2,3,5-tri-O-benzoyl-β-D-ribofuranosyl]pyrrolo[2,3-d]pyrimidine