化合物简介
Darexaban (YM150) is a direct inhibitor of factor Xa created by Astellas Pharma. It is an experimental drug that acts as an anticoagulant and antithrombotic to prevent venous thromboembolism after a major orthopaedic surgery, stroke in patients with atrial fibrillation and possibly ischemic events in acute coronary syndrome. It is used in form of the maleate. The development of darexaban was discontinued in September 2011.
基本信息
中文名称
N-[2-羟基-6-(4-甲氧基苯甲酰氨基)苯基]-4-(4-甲基-1,4-二氮杂庚烷-1-基)苯甲酰胺
英文名称
N-[2-hydroxy-6-[(4-methoxybenzoyl)amino]phenyl]-4-(4-methyl-1,4-diazepan-1-yl)benzamide
中文别名
英文别名
Darexaban、UNII-KF322K101S、Tanexaban
CAS号
365462-23-3
分子式
C27H30N4O4
分子量
474.552
精确质量
474.227
PSA
94.14
LOGP
4.1962
编号系统
UNII
KF322K101S
合成路线
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