化合物简介
Zebularine is a nucleoside analog of cytidine. It is a \"transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.\"; In a small study of mice with a defective Adenomatous polyposis coli gene, oral administration of zebularine to males had no effect on the overall methylation of DNA or the number of polyps, but in females the average number of polyps was reduced from 58 to 1. It has therefore been suggested for drug use as a prototype of epigenetic therapy for cancer chemoprevention.
基本信息
中文名称
4-脱氧尿苷
英文名称
zebularine
中文别名
泽布拉林
英文别名
2(1H)-Pyrimidinone, 1-.β.-D-ribofuranosyl-、[14C]-Zebularine、4-Deoyuridine、2(1H)-PyriMidinone,1-b-D-ribofuranosyl、1--D-Ribofuranosyl-2(1H)-pyrimidinone、Zebularine、4-Deoxyuridine、Pyrimidin-2-one-D-Ribofuranoside
CAS号
3690-10-6
分子式
C9H12N2O5
分子量
228.202
精确质量
228.075
PSA
104.81
LOGP
-2.1452
编号系统
UNII
7A9Y5SX0GY
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