化合物简介
Perampanel, is an antiepileptic drug. It inhibits α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)-induced increases in intracellular Ca2+ and selectively blocks AMPA receptor-mediated synaptic transmission, thus reducing neuronal excitation.
基本信息
中文名称
吡仑帕奈
英文名称
perampanel
中文别名
英文别名
Perampanel、2-(2-oxo-1-phenyl-5-pyridin-2-ylpyridin-3-yl)benzonitrile、3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one、Fycompa、E-2007、5\'-(2-cyanophenyl)-1\'-phenyl-2,3\'-bipyridinyl-6\'(1\'H)-one、2-[1\',6\'-dihydro-6\'-oxo-1-phenyl-(2\',3\'-bipyridin)-5\'-yl]benzonitrile、[14C]-Perampanel
CAS号
380917-97-5
分子式
C23H15N3O
分子量
349.385
精确质量
349.122
PSA
58.68
LOGP
4.43818
编号系统
UNII
H821664NPK
