化合物简介
Triptolide, sold under the brandname Minnelide is a diterpenoid epoxide found in the Thunder God Vine, Tripterygium wilfordii. It has in vitro and in vivo activities against mouse models of polycystic kidney disease and pancreatic cancer, but its physical properties limit its therapeutic potential. Consequently, a synthetic prodrug, minnelide, is being studied clinically instead.
基本信息
中文名称
雷公藤甲素
英文名称
triptolide
中文别名
雷藤素甲、雷公藤内酯醇
英文别名
(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one、TRIPTOLIDE、Triptolide (PG490)、triptolid、PG490、,7as,7bs,8as,8bs)、triptergium wilfordii、(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-6a-isopropyl-8b-methyltrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1(3H)-one、Triptolide?、TRIPTOLIDE TLC、Triptolide(PG490)
CAS号
38748-32-2
分子式
C20H24O6
分子量
360.401
精确质量
360.157
PSA
84.12
LOGP
1.1031
编号系统
UNII
19ALD1S53J
物化性质
外观与性状
白色至灰白色固体
密度
1.48 g/cm3
沸点
601.7ºC at 760 mmHg
熔点
226-227°C
闪点
220.7ºC
折射率
1.647
储存条件
2-8ºC
安全信息
RTECS号
YK7751000
安全说明
S22; S24/25
WGK Germany
3
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