化合物简介
Guggulsterone is a plant steroid found in the resin of the guggul plant, Commiphora mukul. Guggulsterone can exist as either of two stereoisomers, E-guggulsterone and Z-guggulsterone. In humans, it acts as an antagonist of the farnesoid X receptor, which was once believed to result in decreased cholesterol synthesis in the liver. Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone, and levels of low-density lipoprotein (\"bad cholesterol\") increased in many people. Nevertheless, guggulsterone is an ingredient in many nutritional supplements.
基本信息
中文名称
孕二烯二酮
英文名称
(Z)-Guggulsterone
中文别名
顺式-固甾酮
英文别名
Z-Guggulsterone,(Z)-Pregna-4,17(20)-diene-3,16-dione、(17Z)-Pregna-4,17(20)-diene-3,16-dione 4,17(20)-trans-Pregnadiene-3,16-dione
CAS号
39025-23-5
分子式
C21H28O2
分子量
312.446
精确质量
312.209
PSA
34.14
LOGP
4.6436
编号系统
MDL号
MFCD01310757
物化性质
密度
1.1g/cm3
沸点
463.3ºC at 760mmHg
闪点
172.3ºC
折射率
1.557
储存条件
2-8ºC
安全信息
安全说明
S36
危险类别码
R37
危险品标志
Xi